The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line
Paniagua N, Roberts C, Gonzalez L, Monedero-Alonso D, Reinke V. The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line. PLOS Genetics 2024, 20: e1011345. PMID: 38985845, PMCID: PMC11262695, DOI: 10.1371/journal.pgen.1011345.Peer-Reviewed Original ResearchPiRNA genesPiRNA clustersGenomic domainsC. elegans germ lineUpstream sequence transcription complexSmall RNA pathwaysGermline-specific expressionGlobal genome organizationPiRNA precursorsPiRNA pathwayChromosome IVGenome organizationRNA pathwaysChromatin stateTranscribed genesNucleosome positioningNucleosome densityGenome integrityTranscriptional regulationTranscription complexC. elegansPiRNAsGerm lineISW-1Nucleosomal environment