2023
Organ function is preserved despite reorganization of niche architecture in the hair follicle
Wei H, Du S, Parksong J, Pasolli H, Matte-Martone C, Regot S, Gonzalez L, Xin T, Greco V. Organ function is preserved despite reorganization of niche architecture in the hair follicle. Cell Stem Cell 2023, 30: 962-972.e6. PMID: 37419106, PMCID: PMC10362479, DOI: 10.1016/j.stem.2023.06.003.Peer-Reviewed Original ResearchConceptsNiche architectureDermal papilla fibroblastsDifferentiated lineagesHair follicle growthStereotypic architectureMultipotent progenitorsEpithelial progenitorsFunctional importanceNicheStem cellsFibroblast nicheProgenitorsPowerful modelIntravital imagingDermal papillaFibroblastsHair folliclesFollicle growthOrgan functionLineagesDifferentiationCrosstalkHairProliferationCells
2018
Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo
Marsh E, Gonzalez DG, Lathrop EA, Boucher J, Greco V. Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo. Cell 2018, 175: 1620-1633.e13. PMID: 30415836, PMCID: PMC7605015, DOI: 10.1016/j.cell.2018.10.013.Peer-Reviewed Original ResearchConceptsCore cellular mechanismsFibroblast homeostasisRac1-dependent mannerNeighboring fibroblastsMembrane occupancyMembrane extensionsNucleus organizationCellular mechanismsHomeostasisFibroblast membranesAbsence of migrationFibroblastsCell occupancySkin fibroblastsProgressive accumulationVivoStructural componentsLifespan of miceLive miceOccupancyMicePositional stabilityMembraneLifespanAccumulation
1997
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.
Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Research 1997, 57: 1013-9. PMID: 9067261.Peer-Reviewed Original ResearchConceptsDNA rereplicationBiochemical signal transduction pathwaysSignal transduction pathwaysCell cycle checkpointsPRb tumor suppressorSpindle assemblyCycle checkpointsTransduction pathwaysRereplicationDownstream eventsMitotic divisionTumor suppressorMouse fibroblastsCell ploidyDNA contentDeficient derivativeHuman fibroblastsSpindle inhibitorsP53Cytogenetic analysisMitotic spindle inhibitorsFibroblastsPolyploidyMitosisSuppressor