HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity
Xue A, Chapoval SP, Finn ES, Chowdhary VR, Marietta EV, Gaffey TA, Pursifull AC, David CS. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity. Clinical Immunology 2005, 117: 302-315. PMID: 16185928, DOI: 10.1016/j.clim.2005.08.003.Peer-Reviewed Original ResearchConceptsT cell responsesDQ8 miceCell responsesDR4 transgenic miceStrong susceptibility markerEosinophilic inflammatory reactionHLA-DQ8Intranasal instillationIgE productionInflammatory componentHLA-DQ6Tg miceInflammatory reactionSignificant IgG1Transgenic miceInduced hypersensitivityImmunogenic propertiesSusceptibility markersGenetic susceptibilityImmunodominant regionMiceVivo studiesAllergic propertiesHypersensitivityDetergent enzymes