2007
Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus
Chowdhary V, Grande J, Luthra H, David C. Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus. Rheumatology 2007, 46: 1405-1410. PMID: 17576695, DOI: 10.1093/rheumatology/kem117.Peer-Reviewed Original ResearchConceptsAnti-neutrophil cytoplasm antibodiesBronchoalveolar lavagePulmonary capillaritisAntinuclear antibodiesIL-10IL-6IL-4IL-2TNF-alphaIFN-gammaPhosphate-buffered saline injectionEvidence of vasculitisLupus-specific autoantibodiesPristane-induced lupusPristane-injected miceImmune complex depositionSingle intraperitoneal injectionDifferential cell countsPristane injectionAlveolar inflammationCytokine levelsCytoplasm antibodiesLupus lesionsNeutrophil infiltrationEndothelial injury
2005
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity
Xue A, Chapoval SP, Finn ES, Chowdhary VR, Marietta EV, Gaffey TA, Pursifull AC, David CS. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity. Clinical Immunology 2005, 117: 302-315. PMID: 16185928, DOI: 10.1016/j.clim.2005.08.003.Peer-Reviewed Original ResearchConceptsT cell responsesDQ8 miceCell responsesDR4 transgenic miceStrong susceptibility markerEosinophilic inflammatory reactionHLA-DQ8Intranasal instillationIgE productionInflammatory componentHLA-DQ6Tg miceInflammatory reactionSignificant IgG1Transgenic miceInduced hypersensitivityImmunogenic propertiesSusceptibility markersGenetic susceptibilityImmunodominant regionMiceVivo studiesAllergic propertiesHypersensitivityDetergent enzymes