Regional European genetic ancestry predicts type I interferon level and risk of severe viral infection
Nln I, Shum J, Ghodke-Puranik Y, Tipon R, Triese D, Amin S, Makol A, Osborn T, Chowdhary V, Thanarajasingam U, Muskardin T, Oke V, Gunnarsson I, Zickert A, Zervou M, Boumpas D, Svenungsson E, Goulielmos G, Niewold T. Regional European genetic ancestry predicts type I interferon level and risk of severe viral infection. QJM 2024, 117: 581-588. PMID: 38530799, PMCID: PMC11389909, DOI: 10.1093/qjmed/hcae052.Peer-Reviewed Original ResearchType I IFN levelsViral infection outcomesI interferonLupus patientsEuropean genetic ancestryInfection outcomesAnti-viral cytokinesSevere viral infectionsType I interferon levelsHost genetic factorsRisk of severe viral infectionsSevere organ failureI interferon levelsType I IFNType I interferonVirus prior to infectionViral hepatitisOrgan failureGenetic testingViral infectionI IFNOutcome dataHost defenseGenetic factorsGenetic ancestry