HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules
Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules. The Journal Of Immunology 2002, 168: 5876-5884. PMID: 12023392, DOI: 10.4049/jimmunol.168.11.5876.Peer-Reviewed Original ResearchConceptsHLA class II genesImmune responseCell epitopesB-cell epitopesDQ6 miceDQ8 miceSjögren's syndromeClass II genesDominant T cell epitopesMurine class II moleculesSystemic lupus erythematosusHLA class IISera of patientsB cell responsesDominant B-cell epitopesHLA-DR moleculesT cell epitopesClass II moleculesLupus erythematosusAntibody responseDR3 miceCell responsesHigh titersClass IISyndrome