2023
Polysomnography
Jafari B, Mohsenin V. Polysomnography. 2023, 374-387. DOI: 10.1016/b978-0-12-822963-7.00174-2.Peer-Reviewed Original ResearchMovement disordersREM sleep behavior disorderSleep behavior disorderSleep-disordered breathingArterial oxygen saturationSleep stagesREM sleep stagesLimb electromyogramsCardiorespiratory functionRespiratory effortSleep architectureArousal disorderOxygen saturationChin electromyogramDiagnostic utilityOrgan functionPolysomnographyBehavior disorderOral airflowSleepDisordersEye movementsStage WElectromyogramBreathing
2022
Obstructive Sleep Apnea and Polycystic Ovary Syndrome
Chu Y, Hilbert J, Mohsenin V. Obstructive Sleep Apnea and Polycystic Ovary Syndrome. 2022, 393-409. DOI: 10.1007/978-3-030-92589-5_20.Peer-Reviewed Original ResearchPolycystic ovary syndromeObstructive sleep apneaCardiovascular outcomesOvary syndromeSleep apneaPathogenesis of OSAPrevalence of OSARepetitive upper airway obstructionsUntreated sleep-disordered breathingExcess of androgensUpper airway obstructionImproved cardiovascular outcomesSleep-disordered breathingSleep breathing disordersWeight-matched controlsImproved sleep qualityRates of obesityAirway obstructionNorepinephrine levelsCentral adiposityAtypical symptomsInsulin resistanceTreatment optionsSex hormonesTreatment benefit
2021
Pulmonary Hypertension in Obstructive Sleep Apnea
Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.Peer-Reviewed Original ResearchMean pulmonary artery pressurePulmonary hypertensionChronic obstructive pulmonary diseaseMild pulmonary arterial hypertensionPulmonary artery pressurePulmonary arterial hypertensionThird of patientsChronic lung diseaseObstructive pulmonary diseaseObstructive sleep apneaTreatment of OSADaytime hypoxemiaArterial hypertensionArtery pressureObesity hypoventilationHeart failurePulmonary diseaseSleep apneaLung diseaseHypertensionOSAPatientsDiseaseCurrent definitionHypoxemia
2020
Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk Factors
Shojaee A, Mohsenin V. Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk Factors. 2020, a6252-a6252. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6252.Peer-Reviewed Original Research
2018
Treating Sleep-Related Breathing Disorders
Won C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders. 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.Peer-Reviewed Original ResearchPositive airway pressure therapySignificant symptomatic benefitAirway pressure therapySleep-disordered breathingMental health outcomesNeuropsychomotor functionsPAP therapyMainstay treatmentSymptomatic benefitPAP adherenceBreathing disordersPressure therapySide effectsHealth outcomesPatientsTherapyEffective alternativeAdherenceRobust evidenceTolerabilityBreathingSleep
2017
Chapter 122 Sleep and Breathing at High Altitude
Mohsenin V, Javaheri S, Dempsey J. Chapter 122 Sleep and Breathing at High Altitude. 2017, 1211-1221.e4. DOI: 10.1016/b978-0-323-24288-2.00122-7.Peer-Reviewed Original Research
2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysisThe emerging role of microRNAs in hypoxia-induced pulmonary hypertension
Mohsenin V. The emerging role of microRNAs in hypoxia-induced pulmonary hypertension. Sleep And Breathing 2016, 20: 1059-1067. PMID: 27154628, DOI: 10.1007/s11325-016-1351-y.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionHypoxia-induced pulmonary hypertensionPulmonary hypertensionArterial hypertensionHeart failureRole of microRNAsMechanism of PHPulmonary arterial blood pressurePulmonary arterial smooth muscle cellsDevelopment of PHIdiopathic pulmonary arterial hypertensionChronic obstructive lung diseasePathogenesis of PHArterial smooth muscle cellsRight heart failureRight ventricular dysfunctionPoor prognostic signArterial blood pressureCongestive heart failureObstructive lung diseaseSleep-disordered breathingSetting of hypoxiaAberrant vascular remodelingQuality of lifeSmooth muscle cellsModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
2015
Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure.
Redeker NS, Jeon S, Andrews L, Cline J, Jacoby D, Mohsenin V. Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure. Journal Of Clinical Sleep Medicine 2015, 11: 1109-19. PMID: 25979100, PMCID: PMC4582052, DOI: 10.5664/jcsm.5082.Peer-Reviewed Original ResearchConceptsStable heart failureHeart failureSelf-management interventionsChronic insomniaEffect of comorbidityShort-term efficacyInsomnia Severity IndexTreatment of insomniaMeasures of fatigueEffects of CBTAttention control conditionDaytime symptomsPoor functionPreliminary efficacyStable class IWrist actigraphyInsomniaPatientsClass ISeverity IndexEfficacyCBTFunctional performanceTrialsControl conditionPulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology
Kholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.Peer-Reviewed Original ResearchObstructive sleep apneaPulmonary hypertensionPulmonary venous hypertensionVenous hypertensionSleep apneaSetting of OSAPulmonary artery pressurePoor prognostic signHypoxic pulmonary vasoconstrictionMajority of patientsLeft heart dysfunctionAberrant vascular remodelingQuality of lifeResult of apneaVascular cell proliferationArtery pressurePulmonary vasoconstrictionEjection fractionIntermittent hypoxiaPrognostic signHeart dysfunctionLeft heartHigh prevalenceHypertensionVascular remodelingObstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStrokeAssessment of preload and fluid responsiveness in intensive care unit. How good are we?
Mohsenin V. Assessment of preload and fluid responsiveness in intensive care unit. How good are we? Journal Of Critical Care 2015, 30: 567-573. PMID: 25682347, DOI: 10.1016/j.jcrc.2015.01.004.Peer-Reviewed Original ResearchConceptsInferior vena cava diameter variationFluid volume challengeOptimization of hemodynamicsAcute circulatory failureCentral venous pressureIntensive care unitFluid volume resuscitationAssessment of preloadMainstay interventionVasopressor supportTissue hypoperfusionCirculatory failureHypovolemic shockIll patientsOdds of survivalVenous pressureCare unitFluid administrationPulmonary edemaUnstable patientsVolume resuscitationVolume responsivenessBedside approachFluid responsivenessPulse pressure
2014
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea
Jafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaFlow-mediated vasodilationVascular endothelial growth factorYKL-40/chitinaseApnea-hypopnea indexPlasma YKL-40YKL-40Endothelial dysfunctionVasodilatory capacitySleep apneaEndothelial-dependent vasodilatory capacityHypertensive OSANormotensive OSAApparent cardiovascular diseaseRisk of hypertensionProtein 1Events/hrEndothelial growth factorN-OSAVEGF receptor 1Oxygen desaturationSFlt-1Cardiovascular diseaseCommon disorderPositive correlation
2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damageAssessment and management of cerebral edema and intracranial hypertension in acute liver failure
Mohsenin V. Assessment and management of cerebral edema and intracranial hypertension in acute liver failure. Journal Of Critical Care 2013, 28: 783-791. PMID: 23683564, DOI: 10.1016/j.jcrc.2013.04.002.Peer-Reviewed Original ResearchConceptsAcute liver failureLiver failureIntracranial pressureMultiorgan failureCerebral edemaIntracranial hypertensionLiver injuryBrain edemaIngestion of acetaminophenJugular venous oximetryLife-threatening complicationsBrain stem herniationIntracranial pressure monitoringLiver transplantationNeurologic deficitsRare complicationTherapeutic hypothermiaOsmotic therapyVenous oximetryTranscranial DopplerClinical symptomsPrimary insultGrade IIIHypertonic salinePropofol sedationPolysomnography
Jafari B, Mohsenin V. Polysomnography. 2013, 465-474. DOI: 10.1016/b978-0-12-378610-4.00352-1.Peer-Reviewed Original ResearchNarcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool
Mahmoudi M, Won C, Mohsenin V. Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool. Journal Of Sleep Disorders Treatment & Care 2013, 02 DOI: 10.4172/2325-9639.1000106.Peer-Reviewed Original Research
2012
Rehabilitation of stroke and sleep apnea
Jafari B, Mohsenin V. Rehabilitation of stroke and sleep apnea. 2012, 127-138. DOI: 10.1017/cbo9781139061056.013.Peer-Reviewed Original ResearchManagement of sleepSleep apneaSleep disordersPrimary care practitionersRehabilitation of strokeClinical evidenceVascular disturbancesStroke disorderVascular disordersCardiovascular diseasePrevalent conditionVascular pathologyAccurate diagnosisStrokeSleepDiagnosisDisordersApneaBetter diagnosisHypertensionPulmonologistsNeurologistsCardiologistsManagementDiseaseFluid Shift in Obstructive Sleep Apnea: Response
Mohsenin V, Jafari B. Fluid Shift in Obstructive Sleep Apnea: Response. CHEST Journal 2012, 141: 830. DOI: 10.1378/chest.11-3237.Peer-Reviewed Original Research