2016
The emerging role of microRNAs in hypoxia-induced pulmonary hypertension
Mohsenin V. The emerging role of microRNAs in hypoxia-induced pulmonary hypertension. Sleep And Breathing 2016, 20: 1059-1067. PMID: 27154628, DOI: 10.1007/s11325-016-1351-y.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionHypoxia-induced pulmonary hypertensionPulmonary hypertensionArterial hypertensionHeart failureRole of microRNAsMechanism of PHPulmonary arterial blood pressurePulmonary arterial smooth muscle cellsDevelopment of PHIdiopathic pulmonary arterial hypertensionChronic obstructive lung diseasePathogenesis of PHArterial smooth muscle cellsRight heart failureRight ventricular dysfunctionPoor prognostic signArterial blood pressureCongestive heart failureObstructive lung diseaseSleep-disordered breathingSetting of hypoxiaAberrant vascular remodelingQuality of lifeSmooth muscle cells
1994
Human exposure to oxides of nitrogen at ambient and supra-ambient concentrations
Mohsenin V. Human exposure to oxides of nitrogen at ambient and supra-ambient concentrations. Toxicology 1994, 89: 301-312. PMID: 8023333, DOI: 10.1016/0300-483x(94)90102-3.Peer-Reviewed Original ResearchConceptsLevel exposureChronic airway diseasesLow-level exposureHigh-level exposureHuman exposurePredictable clinical responseAirway diseaseClinical responseLung damageLung functionPulmonary edemaAirway irritationEpidemiologic studiesAcute exposureChronic exposureNutritional antioxidantsAdverse effectsLines of evidenceExposureMilitary settingsLow levelsHigh levelsEdemaDiseaseIrritation
1991
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses
Mohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.Peer-Reviewed Original ResearchConceptsElastase inhibitory capacityAlveolar lining fluidLipid peroxidation productsLining fluidLavage fluidVitamin-supplemented groupOxidant stressLipid peroxidationPeroxidation productsControl groupLower respiratory tract fluidFour-week supplementationVitamin CRespiratory tract fluidNO2 exposureInactivation of alphaConjugated dienesVitamin supplementationNormal subjectsAntielastase activityInhibitory capacityOxidant exposureSignificant decreaseAntioxidant defensePeroxidation
1988
Airway responsiveness and prostaglandin generation in scorbutic guinea pigs.
Mohsenin V, Tremml P, Rothberg K, Souhrada M, Douglas J. Airway responsiveness and prostaglandin generation in scorbutic guinea pigs. Prostaglandins Leukotrienes And Essential Fatty Acids 1988, 33: 149-55. PMID: 3186781.Peer-Reviewed Original ResearchConceptsAirway smooth muscleAirway hyperresponsivenessProstaglandin generationGuinea pigsAirway responsivenessHistamine aerosolSmooth muscleScorbutic guinea pigsAscorbic acid-deficient dietSignificant airway hyperresponsivenessScorbutic animalsSodium pump activityElectrogenic sodium pump activityAscorbic acid deficiencyProstanoid generationLung parenchymaDeficient dietElectrophysiological characteristicsControl animalsHyperresponsivenessAcid deficiencyControl groupElectrophysiological propertiesScorbutic conditionLungAirway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects
Mohsenin V. Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects. Archives Of Environmental & Occupational Health 1988, 43: 242-246. PMID: 3289507, DOI: 10.1080/00039896.1988.9934941.Peer-Reviewed Original ResearchConceptsSpecific airway conductanceLung function testsAirway reactivityMethacholine aerosolAirway conductanceFunction testsVital capacityNormal subjectsDouble-blind randomized fashionPartial expiratory flowDose of methacholineConcentration of methacholineAcute respiratory responsesFunctional residual capacityPpm nitrogen dioxideAirway responsesMethacholine inhalationExpiratory volumeRespiratory symptomsNormal nonsmokersExpiratory flowLung volumeRandomized fashionRespiratory responsesResidual capacity
1987
Airway responses to nitrogen dioxide in asthmatic subjects
Mohsenin V. Airway responses to nitrogen dioxide in asthmatic subjects. Journal Of Toxicology And Environmental Health 1987, 22: 371-380. PMID: 3320381, DOI: 10.1080/15287398709531080.Peer-Reviewed Original ResearchConceptsAirway reactivityVital capacityAsthmatic subjectsDouble-blind randomized fashionPartial expiratory flowSpecific airway conductanceDose of methacholineNO2 exposureFunctional residual capacityAirway conductanceAirway responsesMethacholine inhalationExpiratory volumeLung functionExpiratory flowSignificant potentiationSignificant symptomsRandomized fashionRespiratory responsesResidual capacityAsthmaticsCommon indoor air pollutantsExposureSignificant changesDifferent daysEffect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind Experiment
Mohsenin V. Effect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind Experiment. American Journal Of Respiratory And Critical Care Medicine 1987, 136: 1408-1411. PMID: 3318598, DOI: 10.1164/ajrccm/136.6.1408.Peer-Reviewed Original ResearchVitamin C and Airways
MOHSENIN V, DuBOIS A. Vitamin C and Airways. Annals Of The New York Academy Of Sciences 1987, 498: 259-268. PMID: 3304063, DOI: 10.1111/j.1749-6632.1987.tb23766.x.Peer-Reviewed Original Research