2024
Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies
Farooq U, Dragoi G. Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies. Nature Communications 2024, 15: 8417. PMID: 39341810, PMCID: PMC11438871, DOI: 10.1038/s41467-024-52758-9.Peer-Reviewed Original Research
2019
Emergence of preconfigured and plastic time-compressed sequences in early postnatal development
Farooq U, Dragoi G. Emergence of preconfigured and plastic time-compressed sequences in early postnatal development. Science 2019, 363: 168-173. PMID: 30630930, PMCID: PMC6794005, DOI: 10.1126/science.aav0502.Peer-Reviewed Original ResearchConceptsCritical cognitive functionsEpisodic memory formationHippocampal neuronal ensemblesMemory episodesCognitive functionMemory formationPostnatal week 4Postnatal week 3Neuronal ensemblesEarly postnatal developmentElectrophysiological activityNaïve ratsWeek 4Hippocampal neuronsPostnatal developmentWeek 3Eye openingFirst dayEncodingSequential patternsLinear environmentSleepReplay
2015
Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway
Rajkumar R, Wu Y, Farooq U, Tan W, Dawe G. Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway. Brain Research Bulletin 2015, 120: 83-89. PMID: 26529052, DOI: 10.1016/j.brainresbull.2015.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain StemCatheters, IndwellingCold TemperatureDisease Models, AnimalElectrodes, ImplantedFluorescent Antibody TechniqueHippocampusLong-Term PotentiationMaleNeural PathwaysNeuronsNeurotransmitter AgentsPrefrontal CortexProto-Oncogene Proteins c-fosPyrimidinesPyrrolesRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSwimmingConceptsLong-term potentiationNucleus incertusCRF1 receptorCortical pathwaysStress-responsive circuitsStress-induced suppressionHigh-frequency stimulationCRF1 receptor antagonistsC-fos expressionElevation stressStress-related impairmentBrainstem neuronsReceptor antagonistFrequency stimulationSwim stressRodent brainAntalarminReceptorsPathway
2013
Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation
Farooq U, Rajkumar R, Sukumaran S, Wu Y, Tan W, Dawe G. Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation. European Journal Of Neuroscience 2013, 38: 2516-2525. PMID: 23668693, DOI: 10.1111/ejn.12242.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCognitive processesMedial prefrontal cortical activityPrefrontal cortical activityCorticotropin-releasing factor infusionFear memoryCRF infusionPrefrontal cortexCortical activityCortical pathwaysElectrophysiological manipulationsLong-term potentiationMemoryPrelimbic areaNucleus incertusNeuronal firingCorticotropin-releasing factor type 1 receptorFactor type 1 receptorCortical long-term potentiationBrain stem nucleiSpontaneous neuronal firingType 1 receptorHigh-frequency stimulationStressful conditionsStem nuclei