Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway
Rajkumar R, Wu Y, Farooq U, Tan W, Dawe G. Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway. Brain Research Bulletin 2015, 120: 83-89. PMID: 26529052, DOI: 10.1016/j.brainresbull.2015.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain StemCatheters, IndwellingCold TemperatureDisease Models, AnimalElectrodes, ImplantedFluorescent Antibody TechniqueHippocampusLong-Term PotentiationMaleNeural PathwaysNeuronsNeurotransmitter AgentsPrefrontal CortexProto-Oncogene Proteins c-fosPyrimidinesPyrrolesRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSwimmingConceptsLong-term potentiationNucleus incertusCRF1 receptorCortical pathwaysStress-responsive circuitsStress-induced suppressionHigh-frequency stimulationCRF1 receptor antagonistsC-fos expressionElevation stressStress-related impairmentBrainstem neuronsReceptor antagonistFrequency stimulationSwim stressRodent brainAntalarminReceptorsPathwayEvidence of D2 receptor expression in the nucleus incertus of the rat
Kumar J, Rajkumar R, Farooq U, Lee L, Tan F, Dawe G. Evidence of D2 receptor expression in the nucleus incertus of the rat. Physiology & Behavior 2015, 151: 525-534. PMID: 26300469, DOI: 10.1016/j.physbeh.2015.08.024.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAnimalsAntigens, NuclearBlotting, WesternDopamine AgonistsFeeding BehaviorFluorescent Antibody TechniqueHousing, AnimalMaleMotor ActivityNerve Tissue ProteinsQuinpiroleRaphe NucleiRats, Sprague-DawleyReceptors, Dopamine D2Receptors, Dopamine D3RelaxinReverse Transcriptase Polymerase Chain ReactionConceptsReverse transcriptase-polymerase chain reactionNucleus incertusCorticotropin-releasing factor type 1 receptorRelaxin-3Western blottingFactor type 1 receptorD2 receptor activationDopamine type 2 receptorType 1 receptorType 2 receptorD2 receptor expressionTranscriptase-polymerase chain reactionStrong bidirectional connectionsCaudal brainstemGABAergic neuronsNeuN immunoreactivityWidespread projectionsMedian rapheReceptor expressionD2 receptorsHome cage monitoring systemInterpeduncular nucleusD3 receptorsCatecholamine receptorsReceptor activation