2020
Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico
Sharp T, Quandelacy T, Adams L, Aponte J, Lozier M, Ryff K, Flores M, Rivera A, Santiago G, Muñoz-Jordán J, Alvarado L, Rivera-Amill V, Garcia-Negrón M, Waterman S, Paz-Bailey G, Johansson M, Rivera-Garcia B. Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2020, 14: e0008532. PMID: 32956416, PMCID: PMC7529257, DOI: 10.1371/journal.pntd.0008532.Peer-Reviewed Original ResearchConceptsZIKV diseaseDisease casesZika virusZIKV infectionArboviral diseasesEvidence of infectionZika virus diseaseLaboratory-based surveillancePuerto Rico DepartmentPublic health authoritiesIgM ELISAZIKV epidemicHigh incidenceChikungunya virusLaboratory evidenceHealth authoritiesDiseaseEarly detectionRT-PCRInfectionSocioeconomic factorsVirus diseaseEpidemicEarlier midpointIncidence
2017
Differences in Prevalence of Symptomatic Zika Virus Infection, by Age and Sex—Puerto Rico, 2016
Lozier MJ, Burke RM, Lopez J, Acevedo V, Amador M, Read JS, Jara A, Waterman SH, Barrera R, Muñoz-Jordan J, Rivera-Garcia B, Sharp TM. Differences in Prevalence of Symptomatic Zika Virus Infection, by Age and Sex—Puerto Rico, 2016. The Journal Of Infectious Diseases 2017, 217: 1678-1689. PMID: 29216376, PMCID: PMC8849542, DOI: 10.1093/infdis/jix630.Peer-Reviewed Original ResearchConceptsZIKV infectionReverse transcription-polymerase chain reactionEnzyme-linked immunosorbent assaySex-dependent differencesSymptomatic infectionFemale sexSymptomatic Zika virus infectionZika virus infectionSymptomatic ZIKV infectionZika virus diseaseTranscription-polymerase chain reactionNonpregnant womenResidents of householdsZIKV diseaseRecent illnessVirus infectionDisease casesDiagnostic testingStudy participantsInfectionImmunosorbent assayConvenience samplePotential mechanismsChain reactionAgeDengue IgG Seropositivity and Zika Viral Load
Read J, Alvarado L, Torres-Velasquez B, Munoz-Jordan J, Beltran M, Capre S, Adams L, Torres-Torres S, Santiago G, Rivera L, Rivera-Sánchez A, Lorenzi O, Sharp T, Garcia-Gubern C, Waterman S. Dengue IgG Seropositivity and Zika Viral Load. Open Forum Infectious Diseases 2017, 4: s301-s302. PMCID: PMC5631870, DOI: 10.1093/ofid/ofx163.695.Peer-Reviewed Original ResearchPrevious DENV infectionSymptomatic ZIKV infectionDENV IgGDENV infectionZIKV infectionSecondary dengue virus infectionIgG-positive specimensProportion of patientsDengue virus infectionYears of ageIllness surveillance systemZIKV PCRIgG seropositivityRT-PCR resultsLinear regression modelingViral loadIgG assaysPrimary infectionVirus infectionInclusion criteriaStudy populationDENVHouse ELISAInfectionMann-WhitneyPersistence of Zika Virus in Body Fluids — Final Report
Paz-Bailey G, Rosenberg ES, Doyle K, Munoz-Jordan J, Santiago GA, Klein L, Perez-Padilla J, Medina FA, Waterman SH, Adams L, Lozier M, Bertrán-Pasarell J, Garcia Gubern C, Alvarado L, Sharp T. Persistence of Zika Virus in Body Fluids — Final Report. New England Journal Of Medicine 2017, 379: 1234-1243. PMID: 28195756, PMCID: PMC5831142, DOI: 10.1056/nejmoa1613108.Peer-Reviewed Original ResearchZIKV RNAZIKV RNA detectionVaginal secretionsIgM enzyme-linked immunosorbentDetectable ZIKV RNARNA detectionZika virus RNAEnzyme-linked immunosorbentZIKV exposureZIKV infectionWeek 4RNA clearanceZika virusSurveillance sitesFirst monthRT-PCRSerumVirus RNAMonthsBody fluidsUrineSecretionDaysMedianRegression models