2022
Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico
Paz-Bailey G, Sánchez-González L, Torres-Velasquez B, Jones E, Perez-Padilla J, Sharp T, Lorenzi O, Delorey M, Munoz-Jordan J, Tomashek K, Waterman S, Alvarado L, Rivera-Amill V. Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico. The Journal Of Infectious Diseases 2022, 226: 1949-1958. PMID: 35510941, PMCID: PMC10015274, DOI: 10.1093/infdis/jiac165.Peer-Reviewed Original ResearchConceptsSevere plasma leakageSevere dengueReverse transcriptase-polymerase chain reactionPlasma leakageSevere bleedingDengue virusHistory of feverDays of presentationTranscriptase-polymerase chain reactionYear oldsNonsevere dengueOrgan involvementCommon presentationPediatric patientsClinical manifestationsDengue patientsEmergency departmentLaboratory findingsIgM enzymePatientsSerum samplesImmunosorbent assayDengueChain reactionBleeding
2021
Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation
Sharp T, Anderson K, Katzelnick L, Clapham H, Johansson M, Morrison A, Harris E, Paz-Bailey G, Waterman S. Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation. The Lancet Infectious Diseases 2021, 22: e42-e51. PMID: 34265259, PMCID: PMC11379041, DOI: 10.1016/s1473-3099(20)30871-9.Peer-Reviewed Original ResearchConceptsDengue virus infectionSevere dengueVirus infectionDisease severityAnti-dengue virus antibodiesMajor organ failureHospital admissionOrgan failureVaccine evaluationClinical spectrumVaccine trialsPrevious infectionRisk factorsVirus antibodiesClinical studiesClinical practiceDengue virusStudy participantsInfectionLack of specificityHost factorsVirus characteristicsDengueEpidemiologyRange of ages
2015
Indicators for Developing Severe Dengue Identified From a Prospective Acute Febrile Illness Study in Puerto Rico
Pérez-Padilla J, Torres-Velázquez B, Rivera-Sánchez A, Gonzalez E, Torres J, Lugo E, Sharp T, Alvarado L, Tomashek K. Indicators for Developing Severe Dengue Identified From a Prospective Acute Febrile Illness Study in Puerto Rico. Open Forum Infectious Diseases 2015, 2: 112. DOI: 10.1093/ofid/ofv131.32.Peer-Reviewed Original Research
2013
Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico
Ellis E, Pérez-Padilla J, González L, Lebo E, Baker C, Sharp T, Ochoa E, Díaz-Pinto H, Clavell L, Puig-Ramos A, Berzares E, Lupiañez-Merly C, Garcia H, Janka G, Margolis H, Tomashek K. Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico. Blood 2013, 122: 3497. DOI: 10.1182/blood.v122.21.3497.3497.Peer-Reviewed Original ResearchEpstein-Barr virusHemophagocytic lymphohistiocytosisHLH casesDengue virusCause of HLHIncidence of HLHSystemic onset juvenile arthritisAcute febrile illnessAverage annual incidenceSevere dengue casesCase-control studyHerpes simplex virusDengue-endemic areasEnzyme Linked Immunosorbent AssayDENV type 1Linked Immunosorbent AssayDengue BranchFebrile illnessSevere dengueAnnual incidenceClinical outcomesDENV infectionHematologic syndromeHLH criteriaMild feverVirus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico
Sharp TM, Hunsperger E, Santiago GA, Muñoz-Jordan JL, Santiago LM, Rivera A, Rodríguez-Acosta RL, Feliciano L, Margolis HS, Tomashek KM. Virus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2013, 7: e2159. PMID: 23593526, PMCID: PMC3617145, DOI: 10.1371/journal.pntd.0002159.Peer-Reviewed Original ResearchConceptsAcute febrile illnessReverse transcriptase-polymerase chain reactionLaboratory-positive casesPrimary infectionDengue casesDENV-1DENV-2Anti-DENV IgM antibodiesSerum specimenMortality of dengueMosquito-transmitted dengue virusPrimary DENV infectionPassive dengue surveillance systemHealth care providersPrimary prevention interventionsTranscriptase-polymerase chain reactionOnly age groupDENV nucleic acidLaboratory diagnostic dataRates of diseaseFebrile illnessSevere dengueDENV infectionIgM antibodiesDENV antigen