Tyler Sharp, PhD
Cards
Additional Titles
Assistant Professor Adjunct of Epidemiology, Epidemiology of Microbial Diseases
Contact Info
About
Titles
Assistant Professor Adjunct
Assistant Professor Adjunct of Epidemiology, Epidemiology of Microbial Diseases
Biography
Commander Tyler M. Sharp, Ph.D., is an epidemiologist at the Centers for Disease Control and Prevention (CDC) and currently serves as CDC's liaison to the US Department of Defense and Coast Guard.
A native of Bowling Green, Ohio, he attended secondary school in the Chicago area and received his Bachelor of Science degree in Molecular Biology and Genetics from the University of Guelph in Ontario, Canada. He received additional training at Montana State University – Bozeman and the Medical Research Council Division of Virology in Glasgow, Scotland. He completed his doctorate in Molecular Virology and Microbiology at Baylor College of Medicine in Houston, Texas, in the laboratory of Dr. Mary K. Estes where he studied the molecular mechanisms of norovirus pathogenesis. During his graduate study, he received additional training at the National Institute for Infectious Diseases in Tokyo, Japan. He joined CDC in 2010 as an Epidemic Intelligence Service officer stationed at CDC Dengue Branch in San Juan, Puerto Rico, where his public health and research interests included the epidemiology and pathophysiology of emerging infectious diseases, including dengue, Zika, chikungunya, and leptospirosis.
In 2020 he was detailed to the White House Medical Unit to serve as the Chief of Medical Epidemiology. In early 2024 he was appointed as CDC's liaison to the US Department of Defense and Coast Guard, where he is responsible for advocating for CDC interests to US military health partners and provide on-site representation to DoD partners.
CDR Sharp is currently based in Washington, DC, and enjoys international travel, hiking and camping, and SCUBAdiving.
Appointments
Epidemiology of Microbial Diseases
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Epidemiology of Microbial Diseases
- Epidemiology of Microbial Diseases (EMD)
- Yale School of Public Health
- Yale School of Public Health - NEW
Education & Training
- Epidemic Intelligence Service
- U.S. Centers for Disease Control and Prevention (2012)
- PhD
- Baylor College of Medicine, Molecular Virology and Microbiology (2010)
- BS (Hon)
- University of Guelph, Molecular Biology and Genetics (2004)
Research
Overview
Medical Research Interests
Public Health Interests
Research at a Glance
Publications Timeline
Research Interests
Dengue
Puerto Rico
Leptospirosis
Publications
2023
Identification of risk factors and mosquito vectors associated with dengue virus infection in American Samoa, 2017
Sharp T, Tufa A, Cotter C, Lozier M, Santiago G, Johnson S, Mataia’a M, Waterman S, Muñoz-Jordán J, Paz-Bailey G, Hemme R, Schmaedick M, Anesi S. Identification of risk factors and mosquito vectors associated with dengue virus infection in American Samoa, 2017. PLOS Global Public Health 2023, 3: e0001604. PMID: 37418355, PMCID: PMC10328243, DOI: 10.1371/journal.pgph.0001604.Peer-Reviewed Original ResearchAltmetricConceptsDENV infectionIgM ELISARisk factorsRT-PCRDENV-2Dengue virus infectionPopulation-specific risk factorsFrequency of infectionDENV nucleic acidMosquito vectorsOutbreak of dengueCluster investigationsFebrile illnessMedian ageResidents of householdsRole of AeDengue patientsVirus infectionDENV transmissionSerum specimensZika virusPatient specimensBivariate analysisInfectionAdult female mosquitoes
2022
Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico
Paz-Bailey G, Sánchez-González L, Torres-Velasquez B, Jones E, Perez-Padilla J, Sharp T, Lorenzi O, Delorey M, Munoz-Jordan J, Tomashek K, Waterman S, Alvarado L, Rivera-Amill V. Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico. The Journal Of Infectious Diseases 2022, 226: 1949-1958. PMID: 35510941, PMCID: PMC10015274, DOI: 10.1093/infdis/jiac165.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSevere plasma leakageSevere dengueReverse transcriptase-polymerase chain reactionPlasma leakageSevere bleedingDengue virusHistory of feverDays of presentationTranscriptase-polymerase chain reactionYear oldsNonsevere dengueOrgan involvementCommon presentationPediatric patientsClinical manifestationsDengue patientsEmergency departmentLaboratory findingsIgM enzymePatientsSerum samplesImmunosorbent assayDengueChain reactionBleeding
2021
Early Release - Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines - Volume 27, Number 12—December 2021 - Emerging Infectious Diseases journal - CDC
Adams C, Jadi R, Segovia-Chumbez B, Daag J, Ylade M, Medina F, Sharp T, Munoz-Jordan J, Yoon I, Deen J, Lopez A, de Silva A, Premkumar L. Early Release - Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines - Volume 27, Number 12—December 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 3073-3081. PMID: 34808091, PMCID: PMC8632176, DOI: 10.3201/eid2712.211150.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsZIKV seroprevalenceDENV transmissionEnvelope domain IIIZika virusSerologic assaysInfectious Diseases journal - CDCType-specific antibodiesDengue virus serotypesYears of agePublic health laboratoriesRelated flavivirusesHealth laboratoriesFlaviviridae familySeroprevalenceChildren 9Virus serotypesDomain IIIVirusAntibodiesAssaysDENVFlavivirusesKnowledge gaps in the epidemiology of severe dengue impede vaccine evaluation
Sharp T, Anderson K, Katzelnick L, Clapham H, Johansson M, Morrison A, Harris E, Paz-Bailey G, Waterman S. Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation. The Lancet Infectious Diseases 2021, 22: e42-e51. PMID: 34265259, PMCID: PMC11379041, DOI: 10.1016/s1473-3099(20)30871-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDengue virus infectionSevere dengueVirus infectionDisease severityAnti-dengue virus antibodiesMajor organ failureHospital admissionOrgan failureVaccine evaluationClinical spectrumVaccine trialsPrevious infectionRisk factorsVirus antibodiesClinical studiesClinical practiceDengue virusStudy participantsInfectionLack of specificityHost factorsVirus characteristicsDengueEpidemiologyRange of agesFatal Dengue Acquired in Florida
Sharp T, Morris S, Morrison A, de Lima Corvino D, Santiago G, Shieh W, Rico E, Kopp E, Muñoz-Jordán J, Marttos A, Paz-Bailey G, Abbo L, Stanek D. Fatal Dengue Acquired in Florida. New England Journal Of Medicine 2021, 384: 2257-2259. PMID: 34107186, PMCID: PMC11304554, DOI: 10.1056/nejmc2023298.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDengue Virus Infections among Peace Corps Volunteers in Timor-Leste, 2018–2019
Sánchez-González L, Venuto M, Poe S, Major C, Baskara L, Abdiyeva S, Murphy D, Munoz-Jordan J, Medina F, Paz-Bailey G, Petersen K, Becker K, Sharp T. Dengue Virus Infections among Peace Corps Volunteers in Timor-Leste, 2018–2019. American Journal Of Tropical Medicine And Hygiene 2021, 104: 2202-2209. PMID: 33901000, PMCID: PMC8176509, DOI: 10.4269/ajtmh.21-0020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDengue virus infectionMosquito avoidance behaviorsVirus infectionPeace Corps volunteersAnti-DENV IgM antibodiesPeace Corps Medical OfficersOngoing health risksReporting feverDENV infectionIgM antibodiesRecent infectionEpidemiological characteristicsClinical managementMedical recordsMosquito bitesBed netsCollected bloodHealth servicesTravel historyDisease severityDisease controlInfectionMedical officersPreventive measuresDengueEstimating incidence of infection from diverse data sources: Zika virus in Puerto Rico, 2016
Quandelacy T, Healy J, Greening B, Rodriguez D, Chung K, Kuehnert M, Biggerstaff B, Dirlikov E, Mier-y-Teran-Romero L, Sharp T, Waterman S, Johansson M. Estimating incidence of infection from diverse data sources: Zika virus in Puerto Rico, 2016. PLOS Computational Biology 2021, 17: e1008812. PMID: 33784311, PMCID: PMC8034731, DOI: 10.1371/journal.pcbi.1008812.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGuillain-Barré syndrome casesBlood bank dataIncidence of infectionZika virus epidemicSubset of casesSyndrome casesWeekly infectionsUnderlying incidenceZika virusArboviral casesInfectionSurveillance dataEpidemic preparednessZika epidemicVirus epidemicEpidemicIncidenceLarge proportionCasesWeeks
2020
Notes from the Field: Interpretation of Rapid Diagnostic Tests for Leptospirosis During a Dengue Outbreak — Yap State, Federated States of Micronesia, 2019
Dawson P, Marfel M, Galloway R, Tareg A, Paz-Bailey G, Muñoz-Jordán J, Sharp T, Adams L, Bower W. Notes from the Field: Interpretation of Rapid Diagnostic Tests for Leptospirosis During a Dengue Outbreak — Yap State, Federated States of Micronesia, 2019. MMWR Morbidity And Mortality Weekly Report 2020, 69: 1832-1833. PMID: 33270615, PMCID: PMC7714033, DOI: 10.15585/mmwr.mm6948a6.Peer-Reviewed Original ResearchCitationsAltmetricEpidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico
Sharp T, Quandelacy T, Adams L, Aponte J, Lozier M, Ryff K, Flores M, Rivera A, Santiago G, Muñoz-Jordán J, Alvarado L, Rivera-Amill V, Garcia-Negrón M, Waterman S, Paz-Bailey G, Johansson M, Rivera-Garcia B. Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2020, 14: e0008532. PMID: 32956416, PMCID: PMC7529257, DOI: 10.1371/journal.pntd.0008532.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsZIKV diseaseDisease casesZika virusZIKV infectionArboviral diseasesEvidence of infectionZika virus diseaseLaboratory-based surveillancePuerto Rico DepartmentPublic health authoritiesIgM ELISAZIKV epidemicHigh incidenceChikungunya virusLaboratory evidenceHealth authoritiesDiseaseEarly detectionRT-PCRInfectionSocioeconomic factorsVirus diseaseEpidemicEarlier midpointIncidenceClinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases
Sharp T, Keating M, Shieh W, Bhatnagar J, Bollweg B, Levine R, Blau D, Torres J, Rivera A, Perez-Padilla J, Munoz-Jordan J, Sanabria D, Fischer M, Garcia B, Tomashek K, Zaki S. Clinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases. Clinical Infectious Diseases 2020, 73: e345-e354. PMID: 32615591, PMCID: PMC11307670, DOI: 10.1093/cid/ciaa837.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSeptic shockFatal casesTissue specimensMononuclear cellsSplenic follicular dendritic cellsChikungunya virus antigenIntra-alveolar hemorrhageFatal septic shockFollicular dendritic cellsChikungunya virus infectionCommon histopathologic findingsBlood mononuclear cellsReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionCHIKV antigenSevere comorbiditiesAcute illnessClinical characteristicsCHIKV infectionDendritic cellsMedian ageRecord reviewIllness onsetImmunohistochemical findingsHistopathologic findings
Academic Achievements & Community Involvement
honor Juan Carlos Finlay Award
National AwardUnited States Public Health Service, Hispanic Officers Advocacy GroupDetails10/01/2019United Stateshonor Bailey K. Ashford Medal
National AwardThe American Society for Tropical Medicine and HygieneDetails10/28/2018United States