2023
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
Vidyadhara D, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam T, Sames D, Greene L, Sulzer D, Chandra S. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports 2023, 42: 112231. PMID: 36920906, PMCID: PMC10127800, DOI: 10.1016/j.celrep.2023.112231.Peer-Reviewed Original ResearchConceptsParkinson's diseaseMotor deficitsDopamine transporterPathogenesis of PDNigral dopaminergic lossProgressive motor deficitsΑ-synuclein pathologyEarly-onset Parkinson's diseaseDopamine sequestrationDopaminergic vulnerabilityDopaminergic lossKO micePresynaptic sitesKO brainNeurochemical analysisDorsal striatumKnockout miceCardinal featuresReuptake kineticsL-DOPADiseaseSynaptic autophagyFunction mutationsDeficitsMice
2013
A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency
Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limón P, Ren X, Lam TT, Schwartz GJ, de Araujo IE. A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency. Science 2013, 341: 800-802. PMID: 23950538, DOI: 10.1126/science.1239275.Peer-Reviewed Original ResearchConceptsDopamine deficiencyFed miceDietary fatExcess dietary fatBrain dopaminergic functionHigh fat intakeHigh-fat exposureGastrointestinal dysfunctionIntragastric feedingOral intakeDopaminergic functionDopamine releaseExcessive intakeIntakeMiceDeficiencyOleoylethanolamineLipid messengersPhysiological mechanismsFatMotivation deficitsLipid signalingReward sensitivityObesityDysfunction