Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol
Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol. Proteomes 2018, 6: 41. PMID: 30322021, PMCID: PMC6313880, DOI: 10.3390/proteomes6040041.Peer-Reviewed Original ResearchAlcohol use disorderReceptor kinase 2CORT exposureG-Protein Coupled Receptor Kinase 2AR antagonist yohimbineAdolescent stress exposureStress-induced reinstatementAlcohol-motivated behaviorsEarly life stressIntra-amygdala infusionPotential novel mechanismAntagonist yohimbineGlucocorticoid exposureKinase 2Alcohol drinkingCorticosterone exposureLong-term consequencesUse disordersElevated glucocorticoidsGRK2 inhibitorAdrenergic receptorsChronic exposureReinstatement testBrain functionNovel target