2019
Identification of new biomarkers of bronchopulmonary dysplasia using metabolomics
Piersigilli F, Lam TT, Vernocchi P, Quagliariello A, Putignani L, Aghai ZH, Bhandari V. Identification of new biomarkers of bronchopulmonary dysplasia using metabolomics. Metabolomics 2019, 15: 20. PMID: 30830433, DOI: 10.1007/s11306-019-1482-9.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaPreterm neonatesNew biomarkersNeonatal intensive care unitMost preterm infantsIntensive care unitNovel specific biomarkersTracheal aspirate samplesSub-group analysisGestational age differencesPreterm infantsCare unitAspirate samplesNeonatesSpecific biomarkersFirst weekC16-OHIsoleucine levelsSelect metabolitesBiomarkersDysplasiaPartial least squares discriminant analysisLeast squares discriminant analysisSquares discriminant analysisAge differences
2015
MKK3 deletion improves mitochondrial quality
Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P. MKK3 deletion improves mitochondrial quality. Free Radical Biology And Medicine 2015, 87: 373-384. PMID: 26119780, DOI: 10.1016/j.freeradbiomed.2015.06.024.Peer-Reviewed Original ResearchConceptsLPS treatmentMitochondrial membrane potentialIntensive care unitInflammatory cytokine releaseMAP kinase kinase 3Potential therapeutic targetBetter mitochondrial functionMitochondrial functionMitochondrial qualityMouse embryonic fibroblastsCare unitExcessive inflammationCytokine releaseInhibition of mitophagyInflammatory diseasesCytokine secretionInflammatory responseTherapeutic targetLipopolysaccharide (LPS) stimulationSeptic injuryRole of mitophagyMajor causeOxidant productionSevere responseSepsis