Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol
Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol. Proteomes 2018, 6: 41. PMID: 30322021, PMCID: PMC6313880, DOI: 10.3390/proteomes6040041.Peer-Reviewed Original ResearchAlcohol use disorderReceptor kinase 2CORT exposureG-Protein Coupled Receptor Kinase 2AR antagonist yohimbineAdolescent stress exposureStress-induced reinstatementAlcohol-motivated behaviorsEarly life stressIntra-amygdala infusionPotential novel mechanismAntagonist yohimbineGlucocorticoid exposureKinase 2Alcohol drinkingCorticosterone exposureLong-term consequencesUse disordersElevated glucocorticoidsGRK2 inhibitorAdrenergic receptorsChronic exposureReinstatement testBrain functionNovel targetGranulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area
Mervosh NL, Wilson R, Rauniyar N, Hofford RS, Kutlu MG, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area. Proteomes 2018, 6: 35. PMID: 30249060, PMCID: PMC6313867, DOI: 10.3390/proteomes6040035.Peer-Reviewed Original ResearchGranulocyte-colony stimulating factorVentral tegmental areaTegmental areaG-CSF treatmentLimbic brain regionsCombination of cocaineMesolimbic dopamine circuitG-CSF functionInjection of cocaineStudy miceAvailable pharmacotherapiesAberrant plasticityDopamine releaseTreatment groupsSynaptic plasticityDopamine circuitsNeuronal morphologyBrain regionsSoluble cytokinesGranulocyte colonyCocaine addictionBrain functionStimulating factorProtein expressionSignificant toll