2018
Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates
Goel RK, Meyer M, Paczkowska M, Reimand J, Vizeacoumar F, Vizeacoumar F, Lam TT, Lukong KE. Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates. Proteome Science 2018, 16: 16. PMID: 30140170, PMCID: PMC6098843, DOI: 10.1186/s12953-018-0143-7.Peer-Reviewed Original ResearchGlobal phosphoproteomic analysisPhosphoproteomic analysisCellular processesSignaling intermediatesTyrosine kinaseNon-receptor tyrosine kinaseCasein kinase 2 alphaDNA repair pathwaysBRK familyPotential kinasesSubstrate proteinsPhosphorylation dynamicsUpregulated phosphositesSrc familyBioinformatics analysisRepair pathwaysBioinfomatic analysisCandidate substratesBiological processesApoptotic pathwayKinaseIndirect regulationDatabase searchingPhosphoproteomeAnalysis of motives
2017
Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth
Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR, Torrelles JB, Chan J. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth. PLOS Pathogens 2017, 13: e1006515. PMID: 28753640, PMCID: PMC5549992, DOI: 10.1371/journal.ppat.1006515.Peer-Reviewed Original ResearchConceptsPutative ATP-binding cassette transporterCassette transportersATP-binding cassette (ABC) transportersProtein-protein interactionsNon-phosphorylatable alanineVivo growth phenotypesHost-pathogen interactionsCell envelope componentsAffinity chromatography experimentsFHA domainPhosphorylated threonineMutant displaysTwo-hybridGrowth phenotypePutative ATPProtein modulesMutant proteinsPhosphorylated residuesMycobacterial growthBiological processesInositol mannosidesPIM expressionTransportersInteractsEnvelope components