2020
Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit
Britton C, Sorrells T, Johnson A. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit. Science 2020, 367: 96-100. PMID: 31896718, PMCID: PMC8284397, DOI: 10.1126/science.aax5217.Peer-Reviewed Original ResearchMeSH KeywordsEvolution, MolecularFungal ProteinsGene Expression Regulation, FungalGene Regulatory NetworksGenetic CodeHomeodomain ProteinsRegulonTranscription, GeneticYeasts
2013
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains
Lohse M, Hernday A, Fordyce P, Noiman L, Sorrells T, Hanson-Smith V, Nobile C, DeRisi J, Johnson A. Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7660-7665. PMID: 23610392, PMCID: PMC3651432, DOI: 10.1073/pnas.1221734110.Peer-Reviewed Original ResearchMeSH KeywordsCandida albicansChromatin ImmunoprecipitationComputational BiologyDNADNA-Binding ProteinsFungal ProteinsGene DeletionGene Expression ProfilingGene Expression Regulation, FungalGreen Fluorescent ProteinsMultigene FamilyProtein BindingProtein Interaction Domains and MotifsTranscription, GeneticConceptsSequence-specific DNA-binding proteinsDNA-binding domainWhite-opaque switchingDNA-binding proteinsTranscriptional regulatorsOpaque cellsGenome-wide chromatin immunoprecipitationHuman fungal pathogen Candida albicansSequence-specific DNA-binding domainFungal pathogen Candida albicansHeritable cell typesCis-regulatory sequencesGene regulatory proteinsRNA-binding proteinFraction of genesMajor fungal pathogenPathogen Candida albicansDeletion mutant strainAspects of biologySequence-specific mannerGene expression profilingDeep conservationCurrent annotationEvolutionary timeSmall clade