A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile C, Fox E, Nett J, Sorrells T, Mitrovich Q, Hernday A, Tuch B, Andes D, Johnson A. A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans. Cell 2012, 148: 126-138. PMID: 22265407, PMCID: PMC3266547, DOI: 10.1016/j.cell.2011.10.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiofilmsCandida albicansCandidiasis, OralCandidiasis, VulvovaginalCatheter-Related InfectionsDisease Models, AnimalEvolution, MolecularFemaleGene Expression ProfilingGene Expression Regulation, FungalGene Regulatory NetworksGenes, FungalMaleMicroscopy, ConfocalRatsRats, Sprague-DawleyStomatitis, DentureConceptsBiofilm formationPathogenic yeast Candida albicansGenome-wide approachesComplex cell behaviorsAncient genesYeast Candida albicansGenetic screenTranscriptional networksEvolutionary analysisTranscription regulatorsTranscription circuitsMammalian hostsTarget genesBiofilm networksBiofilm developmentCandida albicansGenesCell behaviorIndividual cellsSuspension culturesMedical device-associated infectionsDrug resistanceBiofilmsMicrobesRegulator