2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrain
2006
Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures
Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures. Neurobiology Of Disease 2006, 25: 319-330. PMID: 17112731, DOI: 10.1016/j.nbd.2006.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid Transport System X-AGAstrocytesChildChild, PreschoolDown-RegulationEpilepsyEpilepsy, Temporal LobeExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 2Extracellular FluidFemaleGlutamic AcidHippocampusHumansImmunohistochemistryMaleMicroscopy, Electron, TransmissionMiddle AgedUp-RegulationConceptsTemporal lobe epilepsySclerotic hippocampusNeuronal lossExtracellular glutamateGlial glutamate transporters GLASTHigh extracellular glutamate levelsGroups of hippocampiHuman epileptogenic hippocampusLess neuronal lossExtracellular glutamate levelsGlutamate transporter GLASTGlial glutamate transportersVivo dialysis studyHigh extracellular glutamateSuch compensatory changesEpileptogenic hippocampusHippocampal sclerosisLobe epilepsySclerotic groupSeizure focusGlutamate levelsWeak immunoreactivityGLT-1Glutamate transportersHippocampus
2001
Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex
Eid T, Du F, Schwarcz R. Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex. Epilepsia 2001, 42: 817-824. PMID: 11488878, DOI: 10.1046/j.1528-1157.2001.042007817.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIIIbotenate injectionLobe epilepsySeizure-induced damageLoss of neuronsLayer III neuronsRat entorhinal cortexEpileptic damagePartial neuroprotectionExcitatory afferentsPrimary lesionSeizure activityEntorhinal neuronsAnimal modelsIbotenate lesionsPartial protectionLesionsNeuronsKainatePresubiculumEpilepsySerial reconstructionCortex
2000
Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy?
SCHWARCZ R, EID T, DU F. Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy? Annals Of The New York Academy Of Sciences 2000, 911: 328-342. PMID: 10911883, DOI: 10.1111/j.1749-6632.2000.tb06735.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIILobe epilepsySeizure-induced cell deathProminent excitatory inputSeizure-induced deathLayer III neuronsAminooxyacetic acidAOAA injectionPreferential lesionGABAergic neuronsNeuron lossLimbic structuresExcitatory inputsPathological changesParahippocampal structuresAnimal modelsEpilepsyNeuronsLesionsCell deathCortexDeathInjection
1997
Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study
Du F, Eid T, Schwarcz R. Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study. Neuroscience 1997, 82: 1165-1178. PMID: 9466438, DOI: 10.1016/s0306-4522(97)00354-0.Peer-Reviewed Original ResearchConceptsSilver-stained neuronsTemporal lobe epilepsyEntorhinal cortexAcid injectionNeuronal damageLobe epilepsyLayer IIIProlonged seizure activitySilver impregnation studyReactive glial cellsPattern of neurodegenerationHippocampal CA1 fieldLateral amygdaloid nucleusRat entorhinal cortexAminooxyacetic acidAmino-oxyacetic acidMedial entorhinal cortexDegenerated neuronsNeuropathological consequencesDamaged neuronsSeizure activityAmygdaloid nucleusMost neuronsNeuronal deathCA1 field