Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures
Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures. Neurobiology Of Disease 2006, 25: 319-330. PMID: 17112731, DOI: 10.1016/j.nbd.2006.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid Transport System X-AGAstrocytesChildChild, PreschoolDown-RegulationEpilepsyEpilepsy, Temporal LobeExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 2Extracellular FluidFemaleGlutamic AcidHippocampusHumansImmunohistochemistryMaleMicroscopy, Electron, TransmissionMiddle AgedUp-RegulationConceptsTemporal lobe epilepsySclerotic hippocampusNeuronal lossExtracellular glutamateGlial glutamate transporters GLASTHigh extracellular glutamate levelsGroups of hippocampiHuman epileptogenic hippocampusLess neuronal lossExtracellular glutamate levelsGlutamate transporter GLASTGlial glutamate transportersVivo dialysis studyHigh extracellular glutamateSuch compensatory changesEpileptogenic hippocampusHippocampal sclerosisLobe epilepsySclerotic groupSeizure focusGlutamate levelsWeak immunoreactivityGLT-1Glutamate transportersHippocampus