2001
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking11PDB coordinates have been deposited with the RSCB with accession ID: 1F28.
Anderson A, O’Neil R, Surti T, Stroud R. Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking11PDB coordinates have been deposited with the RSCB with accession ID: 1F28. Cell Chemical Biology 2001, 8: 445-457. PMID: 11358692, DOI: 10.1016/s1074-5521(01)00023-0.Peer-Reviewed Original ResearchConceptsStructure-based drug designProtein targetsDrug designFlexible residuesHigh-resolution crystal structuresProtein/ligand complexesNew conformationDrug leadsEnzyme conformational changeThymidylate synthaseCrystal structureStructure of enzymesPossible conformationsAccession IDConformational adaptationConformational changesLigand complexesExperimental kinetic dataDrug moleculesTarget siteResiduesActive siteAntifolate inhibitorsNovel ligandsKinetic data
1998
Structural models of the bovine papillomavirus E5 protein
Surti T, Klein O, Aschheim K, DiMaio D, Smith S. Structural models of the bovine papillomavirus E5 protein. Proteins Structure Function And Bioinformatics 1998, 33: 601-612. PMID: 9849943, DOI: 10.1002/(sici)1097-0134(19981201)33:4<601::aid-prot12>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsBovine papillomavirus E5 proteinE5 dimerE5 proteinType II integral membrane proteinIntegral membrane proteinsPrevious mutagenesis studiesLigand-independent activationDisulfide-linked homodimerPDGF beta receptorMembrane proteinsTransmembrane orientationMutagenesis studiesMembrane bilayerCell transformationGenetic resultsProteinGln17Receptor moleculesMolecular scaffoldsComplex formationAsp33Computational searchDimerizationDimer structureDimers