2024
Psychotic Disorders and Schizophrenia
Surti T. Psychotic Disorders and Schizophrenia. 2024 DOI: 10.1016/b978-0-323-95702-1.00074-9.Peer-Reviewed Original ResearchPsychotic disordersSymptoms of schizophrenia-spectrum disordersDifferential diagnosis of schizophreniaSchizophrenia spectrum disordersDiagnosis of schizophreniaDecreased emotional expressionNon-psychiatric conditionsAssociated with increased disabilityPsychotic symptomsDisorganized speechDisorganized behaviorCognitive symptomsPsychotic diseasesEmotional expressionSchizophreniaLack of motivationDisordersSymptomsClinical presentationDifferential diagnosisClinical managementDelusionsHallucinationsRisk factorsIncreased mortality
2023
Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia
Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.Peer-Reviewed Original ResearchConceptsGlycine transporter 1Cytochrome P450 2D6 extensive metabolizersGlyT1 inhibitorsWeeks of washoutWeeks of CTMedication adherenceReceptor hypofunctionImpaired neuroplasticityPharmacodynamic variabilityNMDAR functionExtensive metabolizersTreatment periodPsychotic symptomsStable outpatientsCognitive impairmentGlyT1 occupancyTransporter 1CTNeuroplasticityCognitive training strategiesSchizophreniaComputerized CTCognitive performanceAugmentation studiesGreater improvement