2024
Sleep apnea in schizophrenia: Estimating prevalence and impact on cognition
Ghazikhanian S, Surti T. Sleep apnea in schizophrenia: Estimating prevalence and impact on cognition. Journal Of Psychiatric Research 2024, 177: 330-337. PMID: 39068777, DOI: 10.1016/j.jpsychires.2024.07.028.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPrevalence of obstructive sleep apneaCognitive deficits of schizophreniaWorking memory test scoresDeficits of schizophreniaSleep apneaImpaired cognitive domainsSpeed of processingDisabling cognitive deficitsMemory test scoresHigher cognitive capacityFunctional capacity performanceAssociated with lower speedsVerbal learningCognitive domainsCompromised cognitionSchizophreniaRisk of obstructive sleep apneaEffects of sleep apneaCognitive capacityCognitive impairmentPredicting obstructive sleep apneaSelf-reportMedical illnessFunctional capacity assessment
2023
Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia
Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.Peer-Reviewed Original ResearchConceptsGlycine transporter 1Cytochrome P450 2D6 extensive metabolizersGlyT1 inhibitorsWeeks of washoutWeeks of CTMedication adherenceReceptor hypofunctionImpaired neuroplasticityPharmacodynamic variabilityNMDAR functionExtensive metabolizersTreatment periodPsychotic symptomsStable outpatientsCognitive impairmentGlyT1 occupancyTransporter 1CTNeuroplasticityCognitive training strategiesSchizophreniaComputerized CTCognitive performanceAugmentation studiesGreater improvement