Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity
Bi S, Yu D, Si G, Luo C, Li T, Ouyang Q, Jakovljevic V, Sourjik V, Tu Y, Lai L. Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 16814-16819. PMID: 24082101, PMCID: PMC3801017, DOI: 10.1073/pnas.1306811110.Peer-Reviewed Original ResearchConceptsKey interactionsSite-specific mutationsBasic amino acidsMain chain carbonylBacterial chemoreceptorsChemoreceptor TarNonnative ligandsΑ4 helixKey residuesDownstream signalingDiverse stimuliChemotaxis signalingLarge compound librariesMolecular insightsAttractant responseAmino acidsFunctional regionsRegion IChemoeffectorsVivo approachesBinding patternSignalingCompound librariesChemotactic responseAttractants