2015
Regulation of glomerulotubular balance. III. Implication of cytosolic calcium in flow-dependent proximal tubule transport
Du Z, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. III. Implication of cytosolic calcium in flow-dependent proximal tubule transport. American Journal Of Physiology. Renal Physiology 2015, 308: f839-f847. PMID: 25651568, PMCID: PMC4398834, DOI: 10.1152/ajprenal.00601.2014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicarbonatesBiological TransportCalciumCalcium-Transporting ATPasesChelating AgentsCytosolEnzyme InhibitorsIn Vitro TechniquesInositol 1,4,5-Trisphosphate ReceptorsKidney Tubules, ProximalKineticsMice, Inbred C57BLPerfusionRenal ReabsorptionSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsNa/H exchanger 3Luminal Ca(2Flow-induced increaseCytosolic calciumProximal tubulesCa(2+) chelator BAPTA-AMAntagonist 2-aminoethoxydiphenyl borateCa-ATPase inhibitor thapsigarginProximal tubule transportNa(+) reabsorptionMicroperfused in vitroMouse proximal tubuleChelator BAPTA-AMH-ATPase activityNo effectControl tubulesInhibitor thapsigarginBAPTA-AMIntracellular Ca(2Decreased transportTubule transportBaseline transportStimulates Na(+Modulate Na(+Glomerulotubular balance
2002
Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance
Wang T. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. American Journal Of Physiology. Renal Physiology 2002, 283: f658-f662. PMID: 12217856, DOI: 10.1152/ajprenal.00243.2001.Peer-Reviewed Original ResearchConceptsNeuronal nitric oxide synthaseProximal tubulesEndothelial NOSInducible NOSKnockout miceHCO transportEndothelial NOS knockout miceINOS knockout miceMice lacking neuronal nitric oxide synthaseL-N(6)-(1-iminoethyl) lysineInducible NOS knockoutProximal tubule transportNOS knockout miceKidney proximal tubulesWild-typeIsoforms of NOSWild-type controlsNitric oxide synthaseTubule transportMetabolic acidosisModulate Na(+Acid-base statusJ(HCO3Acid-base balanceFluid absorption