The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsEffects of Ang IIProximal convoluted tubulesAng IITMB-8Biphasic effectAngiotensin IISodium transportStimulatory effect of Ang IIPhosphoinositide turnoverN-diethylamino)-octyl-3,4,5-trimethoxybenzoateDose-dependent biphasic effectEffects of angiotensin IIRat proximal convoluted tubuleIntracellular calcium mobilizationRenal tubular transportOriginal perfusatePerfusion in vivoIntracellular calciumNa+/H+ exchangeCalcium mobilizationJHCO3Fluid reabsorptionConvoluted tubulesLuminal perfusionRat kidney