Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC
Sun P, Lin D, Wang T, Babilonia E, Wang Z, Jin Y, Kemp R, Nasjletti A, Wang W. Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. American Journal Of Physiology. Renal Physiology 2006, 291: f1192-f1200. PMID: 16849695, DOI: 10.1152/ajprenal.00112.2006.Peer-Reviewed Original ResearchMeSH Keywords8,11,14-Eicosatrienoic AcidAnimalsArachidonic AcidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEpithelial Sodium ChannelsFemaleIon Channel GatingKidney Tubules, CollectingMaleMembrane PotentialsPatch-Clamp TechniquesRatsRats, Sprague-DawleySodium, DietarySpecific Pathogen-Free OrganismsConceptsExpression of CYP2C23Low Na intakeCollecting ductsMS-PPOHEpoxyeicosatrienoic acidsDistal nephronArachidonic acidNa intakeInhibition of CYP epoxygenaseNa transportNa absorptionArachidonic acid-induced inhibitionControl Na dietInhibition of ENaC.Na-deficient dietNormal-Na dietActivation of ENaCEpithelial Na channelPatch-clamp studiesHigh-Na dietIncreased Na absorptionAA-induced inhibitionInhibitory effectENaC activityNa restriction