2021
Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice
Xu S, Li J, Yang L, Wang CJ, Liu T, Weinstein AM, Palmer LG, Wang T. Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice. Pflügers Archiv - European Journal Of Physiology 2021, 473: 1749-1760. PMID: 34455480, PMCID: PMC8528772, DOI: 10.1007/s00424-021-02611-5.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFemale miceUrine volumeNaCl cotransporterLow K intakeMeasurement of functionSex differencesNatriuretic responseFractional excretionK intakeTransport protein expressionFiltration rateNCC abundanceNCC expressionRenal clearanceDistal nephronLK dietCation excretionPlasma KNCC proteinNKCC2 expressionWestern blottingProtein expressionMiceFENa
2011
GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE
Yan Q, Wan L, Du Z, Gotoh N, Wang T. GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE. The FASEB Journal 2011, 25: 835.9-835.9. DOI: 10.1096/fasebj.25.1_supplement.835.9.Peer-Reviewed Original ResearchGlomerular filtration rateAT2 receptorsUrine volumeProximal tubulesNull miceAngiotensin II type 2 receptorAT1a-/- miceMale null miceType 2 receptorExpression levelsAT1A+/+ miceAT2 inhibitorENaC expressionAT2 expressionKidneys of maleNatriuretic effectWT miceNa+ excretionRenal functionNa+ absorptionReal-time PCRFemale null micePD123319Renal clearanceFiltration rate
2010
Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI
Gotoh N, Yan Q, Du Z, Biemesderfer D, Kashgarian M, Mooseker MS, Wang T. Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI. Cytoskeleton 2010, 67: 178-192. PMID: 20175219, PMCID: PMC3468331, DOI: 10.1002/cm.20435.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsApoptosis Regulatory ProteinsCell TransdifferentiationEndocytosisHorseradish PeroxidaseKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2MiceMice, Neurologic MutantsMicrofilament ProteinsMicrovilliMyosin Heavy ChainsVesicular Transport ProteinsConceptsProximal tubule cellsAlbumin excretionSv miceTubule cellsProximal tubule brush borderGlomerular flow rateProximal tubular dilationUrinary albumin excretionElevated blood pressureReduced body weightProximal tubular endocytosisRenal proximal tubule brush borderTubule brush borderProximal tubular uptakeBlood acid-base parametersMouse kidney proximal tubulesKidney proximal tubulesBlood pressureUrine volumeUrinary excretionAcid-base parametersRenal homogenatesTubular dilationPlasma concentrationsRenal clearance
2007
Blocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice
Yan Q, Du Z, Duan Y, Weinbaum S, Weinstein A, Wang T. Blocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice. The FASEB Journal 2007, 21: a1246-a1246. DOI: 10.1096/fasebj.21.6.a1246-c.Peer-Reviewed Original ResearchGlomerular filtration rateAT1A receptor-deficient miceReceptor-deficient miceUrine volumeAT2 receptorsNa+ excretionAngiotensin II type 2 receptorAdministration of PD123319Handling of Na+Type 2 receptorRenal handling of Na+Renin-angiotensin systemArterial blood pressureRegulation of Na+KO miceIntravenous bolusPD123319Renal clearanceFiltration rateRenal handlingInduce diuresisReceptor functionFluid homeostasisBlood pressureAT1A
2003
The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
Wang T. The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle. Journal Of Pharmacology And Experimental Therapeutics 2003, 304: 833-840. PMID: 12538840, DOI: 10.1124/jpet.102.043380.Peer-Reviewed Original ResearchConceptsLoop of HenleUrine volumeIn vivo microperfusion techniquesCa(2+ATP-sensitive potassium channelsRenal electrolyte transportK channel openerPotassium channel opener minoxidilGlomerular filtration rateApical K(+Fractional Na(+Natriuretic effectAntinatriuretic actionsRenal clearanceFiltration ratePotassium channelsUrinary excretionIncreased fluidAscending limbIntravenous injectionBlood pressureMicroperfusion techniqueHenlePerfusion fluidDecreased Na(+
1995
Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes
Ohno A, Beck F, Pfaller W, Giebisch G, Wang T. Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes. Kidney International 1995, 48: 712-721. PMID: 7474656, DOI: 10.1038/ki.1995.342.Peer-Reviewed Original ResearchConceptsK-ATPase activityProximal tubulesUNX ratsNa/H exchangeBicarbonate absorptionBicarbonate transportResponse to unilateral nephrectomyNa,K-ATPase activityBasolateral ion transportStimulation of bicarbonateBasolateral NaChronic hyperfiltrationMaximal transport rateRemnant kidneyUnilateral nephrectomyCortical tubulesFiltration rateRenal clearanceUNXBicarbonate levelsK-ATPaseRubidium uptakeH secretionFluid absorptionCell ion concentrationsEffects of Glyburide on Renal Tubule Transport and Potassium-Channel Activity
Wang T, Wang W, Klein-Robbenhaar G, Giebisch G. Effects of Glyburide on Renal Tubule Transport and Potassium-Channel Activity. Kidney & Blood Pressure Research 1995, 18: 169-182. PMID: 7481068, DOI: 10.1159/000173914.Peer-Reviewed Original ResearchConceptsK channelsApical membraneInhibition of K secretionApical K channelsRenal tubule transportCortical collecting tubuleK channel activityPatch-clamp techniquePotassium channel activityEffect of glyburideTubule transportK secretionRenal clearanceElectrolyte excretionPotassium channelsTransport of NaAscending limbGlyburideInhibit transportK recyclingKaliuresisHenleMicroperfusionTubulesExcretion