2023
Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma
Sun T, Gilani S, Jain D, Cai G. Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma. Diagnostic Cytopathology 2023, 51: 674-683. PMID: 37469257, DOI: 10.1002/dc.25196.Peer-Reviewed Original ResearchConceptsPancreatic acinar cell carcinomaPancreatic ductal carcinomaAcinar cell carcinomaCell carcinomaMixed acinar-ductal carcinomaMixed acinar-neuroendocrine carcinomaMolecular featuresComprehensive molecular profilingDifferent molecular alterationsDistinct molecular featuresImmunophenotypical featuresNeuroendocrine featuresDuctal carcinomaRare tumorCCDC6-RETCytohistological correlationKi-67Large cohortCytologic diagnosisBiomarker assessmentCytology featuresCytology specimensCarcinomaMolecular alterationsGermline mutationsApplication of the International System for Reporting Serous Fluid Cytopathology to pericardial fluid: Root cause analysis of indeterminate diagnoses, cytohistological correlation, and assessment of malignancy risk
Wang M, Sun T, Jiao J, Wang H. Application of the International System for Reporting Serous Fluid Cytopathology to pericardial fluid: Root cause analysis of indeterminate diagnoses, cytohistological correlation, and assessment of malignancy risk. Cancer Cytopathology 2023, 131: 433-441. PMID: 36973963, DOI: 10.1002/cncy.22696.Peer-Reviewed Original ResearchKRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis
Sun T. KRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis. Future Oncology 2023, 19: 5-6. PMID: 36651534, DOI: 10.2217/fon-2022-0937.Peer-Reviewed Original Research
2022
Risk of malignancy assessment of the International System for Reporting Serous Fluid Cytopathology: Experience in a community hospital setting and comparison with other studies
Sun T, Wang M, Wang H. Risk of malignancy assessment of the International System for Reporting Serous Fluid Cytopathology: Experience in a community hospital setting and comparison with other studies. Cancer Cytopathology 2022, 130: 964-973. PMID: 35994357, DOI: 10.1002/cncy.22638.Peer-Reviewed Original ResearchConceptsCommunity hospital settingPeritoneal effusionPleural effusionSerous Fluid CytopathologyHospital settingInternal review board approvalReview board approvalPleural fluid specimensUndetermined significanceCommunity hospitalEffusion specimensBoard approvalFluid specimensSerous fluidEffusionOverall ROMMalignancyMalignancy assessmentAUSROM analysisNotable heterogeneityAssociated riskReporting terminologyCytopathologyRiskFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokersCytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaCytomorphologic featuresLung carcinomaExtensive antibody panelHigh-grade featuresCommon cytologic featuresDifferent anatomic sitesVariable expressionMajority of casesSquamoid featuresCo-mutated genesUndifferentiated carcinomaImmunohistochemical profileGlandular featuresPapillary architectureAnatomic sitesCytologic featuresAggressive carcinomasClinical informationAntibody panelEpithelial markersScant cytoplasmCarcinomaNuclear enlargementSignificance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review
Sun T, Zuo T, Hui P, Cai G. Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review. Cancer Cytopathology 2022, 130: 558-565. PMID: 35417072, DOI: 10.1002/cncy.22579.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary stenosisKRAS mutation testingKRAS mutational analysisKRAS mutationsBiliary stenosisBiliary ductsInstitutional review board approvalResults of cytologyPancreatic duct adenocarcinomaBiliary brushing cytologyReview board approvalCytological diagnostic categoriesRetrospective reviewBiliary stricturesDuct adenocarcinomaAbsolute riskCytology examinationDuct brushingsBiliary brushingsBrushing cytologyMalignant conditionsCytological diagnosisBoard approvalClinical practiceCytology specimens
2021
Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort
Sun T, Wang X, Wang M, Minerowicz C, Sanchez H, Laskin W, Cohen P, Zhong M. Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort. International Journal Of Surgical Pathology 2021, 30: 512-519. PMID: 34970936, DOI: 10.1177/10668969211070179.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaLung carcinomaCell carcinomaSomatic mutationsClear cell renal cell carcinomaExpression lossCell renal cell carcinomaSquamous cell carcinomaNext-generation sequencingGenetic alterationsRenal cell carcinomaBAP1 protein expressionProtein expression statusStudy cohortNSCLC casesNSCLC tumorsLoss of expressionNeural tumorsAdditional genetic alterationsCommon findingIHC analysisNSCLC carcinogenesisIRB approvalMelanocytic tumorsDiagnostic value of a comprehensive, urothelial carcinoma–specific next‐generation sequencing panel in urine cytology and bladder tumor specimens
Sun T, Hutchinson L, Tomaszewicz K, Caporelli M, Meng X, McCauley K, Fischer AH, Cosar EF, Cornejo KM. Diagnostic value of a comprehensive, urothelial carcinoma–specific next‐generation sequencing panel in urine cytology and bladder tumor specimens. Cancer Cytopathology 2021, 129: 537-547. PMID: 33539671, DOI: 10.1002/cncy.22410.Peer-Reviewed Original ResearchConceptsLow-grade urothelial carcinomaHigh-grade urothelial carcinomaUrine cytology specimensUrothelial carcinomaCytology specimensDiagnostic utilityUrine cytologyNGS panelNext-generation sequencing panelHigh-grade tumorsNext-generation sequencingBiopsy/resectionPossible diagnostic utilityTumor biopsy/resectionCancer Genome AtlasBladder tumorsResection specimensSurgical specimensThinPrep cytologySequencing panelHGUC casesDiagnostic valueCarcinomaCytologyPilot study
2020
Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute
Sun T, Faquin WC, Torous VF. Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute. Cancer Cytopathology 2020, 129: 432-438. PMID: 33296146, DOI: 10.1002/cncy.22395.Peer-Reviewed Original ResearchConceptsFNA casesFine needle aspiration cytologyBenign neoplastic lesionsReview of slidesSalivary gland lesionsObstructive changesTotal cohortRetrospective reviewLymphoepithelial cystRetrospective studyDevelopmental cystsUndetermined significanceCytologic findingsNeoplastic lesionsAspiration cytologySalivary gland fine needle aspiration cytologySurgical pathologyFNA specimensWarthin's tumorGland lesionsDiagnostic categorizationPresence of crystalloidsPleomorphic adenomaCrystalloidsCohortDetermining the significance of psammoma bodies in pelvic washings: A 10‐year retrospective review
Sun T, Pitman MB, Torous VF. Determining the significance of psammoma bodies in pelvic washings: A 10‐year retrospective review. Cancer Cytopathology 2020, 129: 83-89. PMID: 32931128, DOI: 10.1002/cncy.22346.Peer-Reviewed Original ResearchConceptsPelvic washing specimensBorderline tumorsPsammoma bodiesPelvic washingsSerous adenocarcinomaWashing specimensLow-grade serous adenocarcinomaHigh-grade serous adenocarcinomaSerous borderline tumorsEndometrioid endometrial carcinomaBenign processSurgical pathology specimensBorderline diseaseOccult diseaseYounger patientsRetrospective reviewEndometrial carcinomaGynecologic surgeryUncommon findingHistopathologic findingsClinical significanceCytologic analysisRetrospective searchMesothelial hyperplasiaPathology specimensThe Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC)
Sun T, Akalin A, Dresser K, Fischer AH, Zuo T. The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC). Head And Neck Pathology 2020, 15: 389-394. PMID: 32661670, PMCID: PMC8134651, DOI: 10.1007/s12105-020-01202-7.Peer-Reviewed Original ResearchOil red O staining for lipid-laden macrophage index of bronchoalveolar lavage: interobserver agreement and challenges to interpretation
Torous VF, Brackett D, Brown P, Edwin N, Heidarian A, Lobuono C, Sun T, Pitman MB, Ly A. Oil red O staining for lipid-laden macrophage index of bronchoalveolar lavage: interobserver agreement and challenges to interpretation. Journal Of The American Society Of Cytopathology 2020, 9: 563-569. PMID: 32674937, DOI: 10.1016/j.jasc.2020.05.010.Peer-Reviewed Original Research
2019
The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma
Sun T, Hutchinson L, Zhou AG, Liu Q, Cosar EF, St. Cyr M, Ninteau N, Dresser K, Cheng L, Jiang Z, Cornejo KM. The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma. International Journal Of Surgical Pathology 2019, 28: 259-264. PMID: 31640438, DOI: 10.1177/1066896919883016.Peer-Reviewed Original Research
2016
Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, Liu XS. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nature Communications 2016, 7: 10982. PMID: 26975529, PMCID: PMC4796315, DOI: 10.1038/ncomms10982.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBlotting, WesternCell FractionationCell ProliferationChromatin ImmunoprecipitationGene Expression Regulation, NeoplasticGene Regulatory NetworksHCT116 CellsHumansIn Situ Hybridization, FluorescenceMaleMicroRNAsPolycomb Repressive Complex 2Prostatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionRNA TransportRNA, Long NoncodingConceptsRegulatory networksPolycomb repressive complex 2Protein-coding genesProtein-coding transcriptsRepressive complex 2Cancer driver genesGene expression profilesTumor suppressive functionTranscriptional regulationSponge lncRNAsCytoplasmic localizationExpression profilesIntegrative analysisSequence featuresDriver genesLncRNAsPTEN expressionFunctional significanceRegulationGenesRNAExpressionComplexes 2Important roleMicroRNAs