2021
Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort
Sun T, Wang X, Wang M, Minerowicz C, Sanchez H, Laskin W, Cohen P, Zhong M. Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort. International Journal Of Surgical Pathology 2021, 30: 512-519. PMID: 34970936, DOI: 10.1177/10668969211070179.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaLung carcinomaCell carcinomaSomatic mutationsClear cell renal cell carcinomaExpression lossCell renal cell carcinomaSquamous cell carcinomaNext-generation sequencingGenetic alterationsRenal cell carcinomaBAP1 protein expressionProtein expression statusStudy cohortNSCLC casesNSCLC tumorsLoss of expressionNeural tumorsAdditional genetic alterationsCommon findingIHC analysisNSCLC carcinogenesisIRB approvalMelanocytic tumors
2016
Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, Liu XS. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nature Communications 2016, 7: 10982. PMID: 26975529, PMCID: PMC4796315, DOI: 10.1038/ncomms10982.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBlotting, WesternCell FractionationCell ProliferationChromatin ImmunoprecipitationGene Expression Regulation, NeoplasticGene Regulatory NetworksHCT116 CellsHumansIn Situ Hybridization, FluorescenceMaleMicroRNAsPolycomb Repressive Complex 2Prostatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionRNA TransportRNA, Long NoncodingConceptsRegulatory networksPolycomb repressive complex 2Protein-coding genesProtein-coding transcriptsRepressive complex 2Cancer driver genesGene expression profilesTumor suppressive functionTranscriptional regulationSponge lncRNAsCytoplasmic localizationExpression profilesIntegrative analysisSequence featuresDriver genesLncRNAsPTEN expressionFunctional significanceRegulationGenesRNAExpressionComplexes 2Important roleMicroRNAs