Tong Sun, MD, PhD
Assistant Professor of PathologyCards
About
Titles
Assistant Professor of Pathology
Biography
Dr. Sun received her medical degree from Peking University Health Science center and her Ph.D. in molecular oncology from Peking Union Medical College. She joined in Gelb Genitourinary translation research center as a research fellow in Dana-Farber Cancer Institute/Harvard Medical School, where she was later promoted as a research scientist and mainly focused on genetic markers and post-translational regulation mechanism involved in castration resist prostate cancer. She completed residency training in Anatomic and Clinical Pathology at University of Massachusetts Medical School and a Cytopathology Fellowship at the Massachusetts General Hospital. She joined Yale Pathology Staff in 2020. Dr. Sun loves all aspects of general surgical pathology and cytopathology, but has research interests particularly in translational and molecular studies involving gynecological and gentiourinary pathology. She earned Warren R. Lang, MD Resident Physician Award and Journal of American Society of Cytopathology Physician-in-training Award for investigating utility of next-generation sequencing in urine cytology specimens. She has published more than 50 peer-reviewed publications including 5 book chapters and reviews. She serves as a reviewer for 25 scientific journals.
Appointments
Pathology
Assistant ProfessorPrimary
Other Departments & Organizations
- Gynecological Pathology
- Pathology
- Yale Medicine
Education & Training
- Cytopathology Fellow
- Massachusetts General Hospital (2020)
- Resident Physcian
- University of Massachusetts (2019)
- Research Scientist
- Dana-Farber Cancer Institute (2015)
- Postdoctoral Research Fellow
- Dana-Farber Cancer Instittue (2011)
- PhD
- Peking Union Medical College (2007)
- MD
- Peking University (2002)
Research
Publications
2024
Reevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience
Takeda K, Cai G, Adeniran A, Sun T. Reevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience. American Journal Of Clinical Pathology 2024, aqae077. PMID: 38916141, DOI: 10.1093/ajcp/aqae077.Peer-Reviewed Original ResearchCystic fluid cytologyFine-needle aspirationFluid cytologyAmerican College of Obstetricians and Gynecologists guidelinesSingle-institution cohortRate of malignancySurgical pathology diagnosisFNA casesGynecologists guidelinesCytological diagnosisFNA cytologyPathological diagnosisPatient demographicsInstitutional experienceSurgical pathologyOvarian cyst fluidClinical circumstancesAmerican CollegeCytologyRadiological informationMalignancyGold standardCyst fluidModerate sensitivityPotential safety concernsClinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer.
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 10668969241256109. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival time
2023
Cervical and Vaginal Cytology
Sun T, Gilani S. Cervical and Vaginal Cytology. 2023, 35-50. DOI: 10.1007/978-3-031-44289-6_3.Peer-Reviewed Original ResearchPeritoneal Washings and Ovary
Sun T, Gilani S. Peritoneal Washings and Ovary. 2023, 51-56. DOI: 10.1007/978-3-031-44289-6_4.Peer-Reviewed Original ResearchCytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up
Khajir G, Sun T, Wang H, Sprenkle P, Adeniran A, Cai G, Levi A. Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up. Cytopathology 2023, 35: 235-241. PMID: 37916579, DOI: 10.1111/cyt.13328.Peer-Reviewed Original ResearchHigh-grade urothelial carcinomaLow-grade urothelial carcinomaUpper urinary tractUrothelial carcinomaUrinary tractCytologic evaluationCytology specimensInstitutional retrospective studyParis SystemHigh-grade malignancyAtypical urothelial cellsCytologic categoriesRetrospective studyInstitutional databaseCytological diagnosisUrinary cytopathologyHistopathologicMalignant cellsBenign casesUrothelial cellsTPS categoryCarcinomaReporting systemTractAUCCytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma
Sun T, Gilani S, Jain D, Cai G. Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma. Diagnostic Cytopathology 2023, 51: 674-683. PMID: 37469257, DOI: 10.1002/dc.25196.Peer-Reviewed Original ResearchConceptsPancreatic acinar cell carcinomaPancreatic ductal carcinomaAcinar cell carcinomaCell carcinomaMixed acinar-ductal carcinomaMixed acinar-neuroendocrine carcinomaMolecular featuresComprehensive molecular profilingDifferent molecular alterationsDistinct molecular featuresImmunophenotypical featuresNeuroendocrine featuresDuctal carcinomaRare tumorCCDC6-RETCytohistological correlationKi-67Large cohortCytologic diagnosisBiomarker assessmentCytology featuresCytology specimensCarcinomaMolecular alterationsGermline mutationsApplication of the International System for Reporting Serous Fluid Cytopathology to pericardial fluid: Root cause analysis of indeterminate diagnoses, cytohistological correlation, and assessment of malignancy risk
Wang M, Sun T, Jiao J, Wang H. Application of the International System for Reporting Serous Fluid Cytopathology to pericardial fluid: Root cause analysis of indeterminate diagnoses, cytohistological correlation, and assessment of malignancy risk. Cancer Cytopathology 2023, 131: 433-441. PMID: 36973963, DOI: 10.1002/cncy.22696.Peer-Reviewed Original ResearchKRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis
Sun T. KRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis. Future Oncology 2023, 19: 5-6. PMID: 36651534, DOI: 10.2217/fon-2022-0937.Peer-Reviewed Original Research
2022
Risk of malignancy assessment of the International System for Reporting Serous Fluid Cytopathology: Experience in a community hospital setting and comparison with other studies
Sun T, Wang M, Wang H. Risk of malignancy assessment of the International System for Reporting Serous Fluid Cytopathology: Experience in a community hospital setting and comparison with other studies. Cancer Cytopathology 2022, 130: 964-973. PMID: 35994357, DOI: 10.1002/cncy.22638.Peer-Reviewed Original ResearchConceptsCommunity hospital settingPeritoneal effusionPleural effusionSerous Fluid CytopathologyHospital settingInternal review board approvalReview board approvalPleural fluid specimensUndetermined significanceCommunity hospitalEffusion specimensBoard approvalFluid specimensSerous fluidEffusionOverall ROMMalignancyMalignancy assessmentAUSROM analysisNotable heterogeneityAssociated riskReporting terminologyCytopathologyRiskFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokers