Featured Publications
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes. Cell 2012, 149: 1298-1313. PMID: 22682250, PMCID: PMC3529917, DOI: 10.1016/j.cell.2012.03.047.Peer-Reviewed Original ResearchConceptsComplement C1qWnt coreceptor low-density lipoprotein receptor-related protein 6Canonical Wnt signalingLow-density lipoprotein receptor-related protein 6Serum C1q concentrationLipoprotein receptor-related protein 6Age-related phenotypesWild-type miceAge-associated impairmentWnt signalingMuscle regenerationAge-associated declineYoung miceC1q treatmentC1q concentrationsSkeletal muscle regenerationMammalian agingMiceProtein 6C1qC1s inhibitionCanonical WntMultiple tissuesFrizzled receptorsWnt
2015
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression
Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I. Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports 2015, 5: 14453. PMID: 26571361, PMCID: PMC4585890, DOI: 10.1038/srep14453.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAgingAngiotensin II Type 1 Receptor BlockersAnimalsAxin ProteinBiphenyl CompoundsCell LineComplement C1qDown-RegulationImmunohistochemistryIrbesartanMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalPAX7 Transcription FactorReceptor, Angiotensin, Type 1RegenerationTetrazolesWnt Signaling PathwayConceptsC1q expressionReceptor blockadeAge-related declineAngiotensin II receptor blockadeAT1 receptor blocker irbesartanAngiotensin II type 1 receptorII type 1 receptorAT1 receptor blockadeFunctional muscle recoveryII receptor blockadeSkeletal muscleReceptor blocker irbesartanType 1 receptorWnt/β-catenin pathwaySkeletal muscle functionWnt/β-catenin signalingMuscle regenerationΒ-catenin pathwayCultured macrophage cellsΒ-catenin signalingAT1 receptorMuscle recoveryM2 polarizationMuscle functionTopical administration