A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling
Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I. A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling. PLOS ONE 2015, 10: e0137106. PMID: 26327560, PMCID: PMC4556625, DOI: 10.1371/journal.pone.0137106.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntioxidantsAtrial Natriuretic FactorConnective Tissue Growth FactorDietFibroblastsFibrosisFlavonoidsFoodHeartHydrogen PeroxideHypertrophyLuteolinMaleMyocardiumOxidative StressPhosphorylationRatsRats, Sprague-DawleySignal TransductionTransforming Growth Factor beta1Ventricular RemodelingConceptsCardiac remodelingAng IIOral pretreatmentII-Induced Cardiac RemodelingOxidative stressCultured rat cardiac fibroblastsRat cardiac fibroblastsPhosphorylation of JNKHyperoxidative stateAntifibrotic effectsCardiac fibrosisCardiac functionLuteolin pretreatmentTGFβ1 expressionCardiac fibroblastsPotent antioxidantHerbal extractsProtective actionCardiac tissueRemodelingExpression levelsGene expression levelsDietPretreatmentProtective properties