Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target
Brighenti T, Neri G, Mazzola M, Tomé G, Scalfati M, Peroni D, Belli R, Zampedri E, Tebaldi T, Borello U, Romanelli F, Casarosa S. Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target. Clinical Proteomics 2024, 21: 63. PMID: 39609746, PMCID: PMC11603643, DOI: 10.1186/s12014-024-09515-3.Peer-Reviewed Original ResearchRhegmatogenous retinal detachmentDiabetic retinopathyNon-steroidal anti-inflammatory drugsRetinal detachmentVitreoretinal diseasesPotential therapeutic targetProliferative vitreoretinopathyOphthalmic non-steroidal anti-inflammatory drugTherapeutic targetAnalysis of vitreous samplesProteomic signatureGlucose metabolismNitric oxide levelsAnti-inflammatory drugsElevated nitric oxide levelsMacular puckerPhotoreceptor deathImprove quality of lifeAldo-keto reductase family 1 member B1Vitreous samplesRetinal cellsVascular proliferationFibrous proliferationReduce complicationsHuman vitreous