2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiography
1994
BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat
Graham G, Zhong J, Petroff O, Constable R, Prichard J, Gore J. BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat. Magnetic Resonance In Medicine 1994, 31: 557-560. PMID: 8015411, DOI: 10.1002/mrm.1910310514.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientNormal human subjectsMRI changesCerebral perfusionCerebrovascular reserveCerebrovascular diseaseAnatomic mappingRatsMRI monitoringSignificant decreaseHuman subjectsMRI methodsMRI signalHypercarbiaPatientsInhalationPerfusionReactivity patternsAcetazolamideDiseaseAdministration