2023
Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance
Ju S, Horien C, Shen X, Abuwarda H, Trainer A, Constable R, Fredericks C. Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance. Frontiers In Dementia 2023, 2: 1126016. PMID: 39082002, PMCID: PMC11285565, DOI: 10.3389/frdem.2023.1126016.Peer-Reviewed Original ResearchDefault mode networkConnectome-based predictive modelingMemory performanceMemory taskMemory scoresShort-term memory performanceBrain-based predictorsShort-term memoryPosterior default mode networkAmnestic Alzheimer's diseaseRecollective memoryDMN activityMode networkVisual networkPast researchSex-specific modelsVisual circuitryAlzheimer's diseaseSex differencesMemoryDifferent circuitryTaskElevated riskMachine learning approachesNetwork activity
2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settings
2021
Functional Connectivity during Encoding Predicts Individual Differences in Long-Term Memory
Lin Q, Yoo K, Shen X, Constable TR, Chun MM. Functional Connectivity during Encoding Predicts Individual Differences in Long-Term Memory. Journal Of Cognitive Neuroscience 2021, 33: 2279-2296. PMID: 34272957, PMCID: PMC8497062, DOI: 10.1162/jocn_a_01759.Peer-Reviewed Original ResearchConceptsLong-term memoryN-back taskIndividual differencesFunctional connectivityMemory modelWhole-brain functional connectivity networksSubsequent memory effectsRecognition memory modelsMedial temporal lobeWhole-brain functional networksRetention of informationRecollection memoryRecognition memoryMemory performanceNeural basisFunctional connectivity networksLTM formationFMRI dataTemporal lobeMemoryBrain regionsFunctional networksConnectivity networksTaskLittle predictive power
2018
Combining Multiple Connectomes via Canonical Correlation Analysis Improves Predictive Models
Gao S, Greene A, Todd Constable R, Scheinost D. Combining Multiple Connectomes via Canonical Correlation Analysis Improves Predictive Models. Lecture Notes In Computer Science 2018, 11072: 349-356. DOI: 10.1007/978-3-030-00931-1_40.Peer-Reviewed Original ResearchTask conditionsDifferent cognitive tasksMultiple task conditionsDifferent task conditionsConnectivity dataDifferent cognitive conditionsFunctional connectivity dataComputational modelHuman Connectome ProjectPrediction of behaviorCognitive tasksIndividual differencesBehavioral measuresBehavioral predictionsCognitive conditionsMultiple connectomesSingle taskFunctional connectivityConnectome ProjectDifferent tasksComplementary informationMultiple tasksTaskPrincipled methodCanonical correlation analysisTask-induced brain state manipulation improves prediction of individual traits
Greene AS, Gao S, Scheinost D, Constable RT. Task-induced brain state manipulation improves prediction of individual traits. Nature Communications 2018, 9: 2807. PMID: 30022026, PMCID: PMC6052101, DOI: 10.1038/s41467-018-04920-3.Peer-Reviewed Original ResearchConceptsBrain statesIndividual differencesBrain-behavior relationshipsFluid intelligence scoresTask-based functional connectivity analysisResting-state fMRI dataBrain functional organizationFunctional connectivity analysisCognitive tasksFluid intelligenceIntelligence scoresFunctional connectivityFMRI dataConnectivity analysisHuman behaviorIndividual traitsTaskCertain tasksFunctional organizationOutperform modelsSuch relationshipsCognitionState manipulationIntelligenceVarianceTask Integration for Connectome-Based Prediction Via Canonical Correlation Analysis
Gao S, Greene A, Constable R, Scheinost D. Task Integration for Connectome-Based Prediction Via Canonical Correlation Analysis. 2018, 87-91. DOI: 10.1109/isbi.2018.8363529.Peer-Reviewed Original ResearchTask conditionsDifferent tasksDifferent cognitive tasksMultiple task conditionsDifferent task conditionsConnectivity dataDifferent cognitive conditionsFunctional connectivity dataHuman Connectome ProjectComputational modelPrediction of behaviorCognitive tasksFluid intelligenceIndividual differencesBehavioral measuresBehavioral predictionsCognitive conditionsSingle taskFunctional connectivityConnectome ProjectComplementary informationTask integrationTaskProof of conceptCanonical correlation analysis
2017
Can brain state be manipulated to emphasize individual differences in functional connectivity?
Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.Peer-Reviewed Original ResearchConceptsIndividual differencesFunctional connectivityBrain statesIndividual differences researchBrain functional organizationHuman Connectome ProjectDifferences researchBrain activityConnectome ProjectSubject variabilityNetworks of interestBehavioral phenotypesCertain tasksFunctional organizationDefault stateNeutral backdropOutline questionsFuture studiesConnectivityTask
2009
Language lateralization in epilepsy patients: fMRI validated with the Wada procedure
Arora J, Pugh K, Westerveld M, Spencer S, Spencer DD, Constable R. Language lateralization in epilepsy patients: fMRI validated with the Wada procedure. Epilepsia 2009, 50: 2225-2241. PMID: 19490042, DOI: 10.1111/j.1528-1167.2009.02136.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVerbal fluency taskWada procedureSentence comprehensionFluency taskLaterality scoresLanguage lateralizationLaterality indexAuditory sentence comprehensionFMRI language mappingAuditory taskReading taskConjunction analysisHemispheric dominanceLateralization scoresFMRI laterality indicesLanguage mappingWada testingMidline regionWada testLateralizationSpecific patient examplesQuantifying activationTaskComprehension
2006
Brain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortex
2004
Attentional bias for valenced stimuli as a function of personality in the dot-probe task
Amin Z, Constable R, Canli T. Attentional bias for valenced stimuli as a function of personality in the dot-probe task. Journal Of Research In Personality 2004, 38: 15-23. DOI: 10.1016/j.jrp.2003.09.011.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAttentional biasAttentional tasksDot-probe taskDimensions of affectFunction of personalityDimensions of personalityValenced stimuliAttentional probeEmotional stimuliNegative affectFusiform gyrusVisual searchGreater activationAutonomic arousalBrain regionsVisual fieldTaskAffectPersonalityIncreased effortStimuliMagnetic resonance imagingBiasNeuroticism
2001
The neurobiology of dyslexia
Shaywitz B, Shaywitz S, Pugh K, Fulbright R, Mencl W, Constable R, Skudlarski P, Fletcher J, Lyon G, Gore J. The neurobiology of dyslexia. Clinical Neuroscience Research 2001, 1: 291-299. DOI: 10.1016/s1566-2772(01)00015-9.Peer-Reviewed Original ResearchPhonological processingNeural systemsNeurobiology of dyslexiaPosterior brain systemsFrontal lobe circuitsDiagnosis of dyslexiaFunctional brain imagingDevelopment of tasksSubcomponent processesCognitive modelCognitive basisReading taskBrain systemsNeural substratesDyslexiaBrain organizationParticular subcomponentLanguage systemBrain imagingSpecific hypothesesTaskAdditional suggestionsReadingProcessingAdultsThe Functional Neural Architecture of Components of Attention in Language-Processing Tasks
Shaywitz B, Shaywitz S, Pugh K, Fulbright R, Skudlarski P, Mencl W, Constable R, Marchione K, Fletcher J, Klorman R, Lacadie C, Gore J. The Functional Neural Architecture of Components of Attention in Language-Processing Tasks. NeuroImage 2001, 13: 601-612. PMID: 11305889, DOI: 10.1006/nimg.2000.0726.Peer-Reviewed Original ResearchConceptsInferior frontal sitesFrontal sitesAttentional controlExecutive functionFunctional neural architectureFunctional magnetic resonanceLanguage processing tasksLeft hemisphere sitesSelective attentionPerceptual selectivityRight-handed manParietal sitesRight hemisphereCortical systemsLanguage processingNeural architectureFrontal cortexIncreased activationHemisphere sitesWordsTaskImportant dimensionSpecific functional aspectsAttentionProcessing
2000
Functional neuroanatomy of executive processes involved in dual-task performance
Adcock R, Constable R, Gore J, Goldman-Rakic P. Functional neuroanatomy of executive processes involved in dual-task performance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 3567-3572. PMID: 10725387, PMCID: PMC16280, DOI: 10.1073/pnas.97.7.3567.Peer-Reviewed Original ResearchConceptsDual-task paradigmDual-task performanceComponent tasksExecutive systemExecutive processesCentral executive systemSupervisory Attentional SystemAttentional resourcesAttentional systemExecutive functionTask performanceFunctional neuroanatomyMost current modelsSecond taskSubjective experienceFunctional MRIBrain functionTaskContradictory findingsCognitionDual conditionsDistinct systemsParadigmCurrent modelsNeuroanatomyThe Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex
Pugh K, Mencl W, Shaywitz B, Shaywitz S, Fulbright R, Constable R, Skudlarski P, Marchione K, Jenner A, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Gore J. The Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex. Psychological Science 2000, 11: 51-56. PMID: 11228843, DOI: 10.1111/1467-9280.00214.Peer-Reviewed Original ResearchConceptsDevelopmental dyslexiaAngular gyrusFunctional connectivityPhonological assemblyLeft hemispherePhonological processing domainTask-specific differencesLanguage-dominant left hemispherePosterior brain regionsTemporal lobe sitesDyslexic readersNeurobiological anomaliesPhonological performanceExplicit demandDyslexiaBrain regionsGyrusPosterior cortexTaskCompensatory roleVaried demandsPosterior regionDyslexicsConnectivityHemisphere
1997
Predicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification
Pugh K, Shaywitz B, Shaywitz S, Shankweiler D, Katz L, Fletcher J, Skudlarski P, Fulbright R, Constable R, Bronen R, Lacadie C, Gore J. Predicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification. Journal Of Experimental Psychology Human Perception & Performance 1997, 23: 299-318. PMID: 9103996, DOI: 10.1037/0096-1523.23.2.299.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPhonological effectsLexical decision taskLexical decision latenciesLexical-semantic processesBrain activation patternsWord identificationWord recognitionDecision taskDecision latenciesRegularity effectIndividual differencesFMRI measuresHemispheric lateralizationCerebral basisExperimental paradigmActivation patternsCortical regionsLength effectYoung adultsTaskParticipantsReadingMeasuresMagnetic resonance imagingNeuroanatomy of Reading and Dyslexia
Fulbright R, Shaywitz S, Shaywitz B, Pugh K, Skudlarski P, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Bronen R, Marchione K, Gore J. Neuroanatomy of Reading and Dyslexia. Child And Adolescent Psychiatric Clinics Of North America 1997, 6: 431-446. DOI: 10.1016/s1056-4993(18)30312-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPhonologic processingInferior frontal gyrus regionsCore cognitive componentLexical-semantic processingWord identificationNeural signaturesCognitive componentsComponent processesDyslexiaLinguistic systemGyrus regionsFunctional MR imagingConsistent findingProcessingReadingOrthographyPhonologyTaskNeuroanatomyDeficitsChildrenAdultsDisordersBrainFindings
1996
Auditory Selective Attention: An fMRI Investigation
Pugh K, Shaywitz B, Shaywitz S, Fulbright R, Byrd D, Skudlarski P, Shankweiler D, Katz L, Constable R, Fletcher J, Lacadie C, Marchione K, Gore J. Auditory Selective Attention: An fMRI Investigation. NeuroImage 1996, 4: 159-173. PMID: 9345506, DOI: 10.1006/nimg.1996.0067.Peer-Reviewed Original ResearchConceptsAttention systemAnterior attention systemPosterior attention systemAuditory selective attentionInferior frontal regionsInferior frontal gyrusMiddle temporal gyrusDichotic listening conditionsSelective attentionFMRI investigationSpeech tokensPitch judgmentsFrontal gyrusListening conditionsBroca's areaTemporal gyrusNonspeech tasksHemispheric differencesFrontal regionsTone stimuliDichotic conditionsCingulate gyrusGyrusPresent experimentsTaskThe Functional Organization of Brain for Reading and Reading Disability (Dyslexia
Shaywitz B, Shaywitz S, Pugh K, Skudlarski P, Fulbright R, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Bronen R, Marchione K, Lacadie C, Gore J. The Functional Organization of Brain for Reading and Reading Disability (Dyslexia. The Neuroscientist 1996, 2: 245-255. DOI: 10.1177/107385849600200413.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingPhonological processingLeft inferior frontal gyrusCore cognitive componentLexical-semantic processingInferior frontal gyrusFunctional organizationPhonological tasksCognitive componentsIFG regionsReading DisabilitiesFrontal gyrusComponent processesLanguage functionBilateral activationLinguistic systemWomen's performanceDyslexiaSex differencesReadingConsistent findingCerebral localizationProcessingTaskLanguageFunctional magnetic resonance imaging of frontal cortex during performance of non-spatial associative memory tasks
Adcock R, Constable R, Gore J, Goldman-Rakic P. Functional magnetic resonance imaging of frontal cortex during performance of non-spatial associative memory tasks. NeuroImage 1996, 3: s526. DOI: 10.1016/s1053-8119(96)80528-3.Peer-Reviewed Original Research
1995
Sex differences in the functional organization of the brain for language
Shaywitz B, Shaywltz S, Pugh K, Constable R, Skudlarski P, Fulbright R, Bronen R, Fletcher J, Shankweiler D, Katz L, Gore J. Sex differences in the functional organization of the brain for language. Nature 1995, 373: 607-609. PMID: 7854416, DOI: 10.1038/373607a0.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus regionsInferior frontal gyrus regionsRight inferior frontal gyrusSex differencesInferior frontal gyrusFunctional organizationPattern of activationRight-handed subjectsPhonological processingPhonological tasksSemantic tasksBrain activationFrontal gyrusLanguage functionNeural systemsGyrus regionsCerebral hemispheresTaskLanguageBrainGyrusOrganizationMalesProcessingActivation