2023
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study
van Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossCerebral neuronal activityStriatal dopamine releaseWeight lossCrossover studyDopamine releaseNeuronal activityIntragastric glucoseNeuronal responsesSuccessful weight lossHealthy body weightSignificant weight lossBrain responsesPathological feeding behaviorsWeight regainHunger scoresLipid infusionLean participantsCaloric intakePlasma hormonesObesityBody weightInfusionNutrient signalsHigh rate
2008
Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing
Canli T, Congdon E, Constable R, Lesch K. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological Psychology 2008, 79: 118-125. PMID: 18314252, DOI: 10.1016/j.biopsycho.2008.01.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEvent-related potentialsNeutral facial expressionsSpecific neural lociWord stimuliEmotional scenesAffective processingAffective stimuliEmotional stimuliVerbal stimuliNeural correlatesIndividual differencesNeural processingNeural locusBrain responsesFacial expressionsConvergent evidenceIndependent study samplesFMRI dataRobust effectCortical regionsStimuliTPH2 genotypeTryptophan hydroxylase 2 geneCurrent study