2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesLow‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imaging
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelin
2019
The individual functional connectome is unique and stable over months to years
Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.Peer-Reviewed Original ResearchConceptsHigh ID ratesIndividual differencesFunctional connectomeIndividual functional connectomesStable individual differencesID rateResting-state fMRI datasetsFrontoparietal networkFunctional connectivityParietal cortexFMRI datasetsIdiosyncratic aspectsConnectomeHead motionEntire brainFMRIBrainCortexSpecific datasetDifferencesConnectivity
2018
Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity
GROSKREUTZ D, HWANG J, SEO D, LACADIE C, PARIKH L, BELFORT-DEAGUIAR R, SCHEINOST D, SINHA R, CONSTABLE T, SHERWIN R. Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity. Diabetes 2018, 67 DOI: 10.2337/db18-11-lb.Peer-Reviewed Original ResearchDefault mode networkHypoglycemia awarenessDMN connectivityAvoidance of hypoglycemiaDefault mode network connectivityHypoglycemia symptom scoresMode network connectivityBrain connectivity patternsBOLD-fMRI scanningMannKind CorporationT1DM individualsHypoglycemia unawarenessHypoglycemic clampSymptom scoresRegeneron PharmaceuticalsGlaxoSmithKline plcPlasma cortisolState connectivityMode networkFMRI scanningHypoglycemiaElicit changesBrainFunctional networksConnectivity patterns
2004
Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor Imaging
Jackowski M, Kao C, Qiu M, Constable R, Staib L. Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor Imaging. Lecture Notes In Computer Science 2004, 3217: 663-670. DOI: 10.1007/978-3-540-30136-3_81.Peer-Reviewed Original ResearchFront arrival timesFront propagationAnisotropic front propagationMagnetic resonance imagingNormal human brainDiffusion tensor imagingDiffusion tensor magnetic resonance imagingAnisotropic versionWhite matterPropagation methodResonance imagingAnatomical connectivityFibrous tissueTensor imagingDiffusion tensorHuman brainSweeping methodArrival timeBrain
1998
Functional disruption in the organization of the brain for reading in dyslexia
Shaywitz S, Shaywitz B, Pugh K, Fulbright R, Constable R, Mencl W, Shankweiler D, Liberman A, Skudlarski P, Fletcher J, Katz L, Marchione K, Lacadie C, Gatenby C, Gore J. Functional disruption in the organization of the brain for reading in dyslexia. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 2636-2641. PMID: 9482939, PMCID: PMC19444, DOI: 10.1073/pnas.95.5.2636.Peer-Reviewed Original ResearchConceptsBrain activation patternsActivation patternsDyslexic readersFunctional disruptionFunctional magnetic resonanceAlphabetic charactersRelative underactivationPhonologic awarenessNeural signaturesPhonologic analysisSpoken wordsAnterior regionImpairmentNeural systemsPosterior regionDyslexiaMagnetic resonanceWordsOveractivationBrain
1997
Neuroanatomy of Reading and Dyslexia
Fulbright R, Shaywitz S, Shaywitz B, Pugh K, Skudlarski P, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Bronen R, Marchione K, Gore J. Neuroanatomy of Reading and Dyslexia. Child And Adolescent Psychiatric Clinics Of North America 1997, 6: 431-446. DOI: 10.1016/s1056-4993(18)30312-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPhonologic processingInferior frontal gyrus regionsCore cognitive componentLexical-semantic processingWord identificationNeural signaturesCognitive componentsComponent processesDyslexiaLinguistic systemGyrus regionsFunctional MR imagingConsistent findingProcessingReadingOrthographyPhonologyTaskNeuroanatomyDeficitsChildrenAdultsDisordersBrainFindings
1995
Sex differences in the functional organization of the brain for language
Shaywitz B, Shaywltz S, Pugh K, Constable R, Skudlarski P, Fulbright R, Bronen R, Fletcher J, Shankweiler D, Katz L, Gore J. Sex differences in the functional organization of the brain for language. Nature 1995, 373: 607-609. PMID: 7854416, DOI: 10.1038/373607a0.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus regionsInferior frontal gyrus regionsRight inferior frontal gyrusSex differencesInferior frontal gyrusFunctional organizationPattern of activationRight-handed subjectsPhonological processingPhonological tasksSemantic tasksBrain activationFrontal gyrusLanguage functionNeural systemsGyrus regionsCerebral hemispheresTaskLanguageBrainGyrusOrganizationMalesProcessingActivation
1993
Functional brain imaging at 1.5 T using conventional gradient echo MR imaging techniques
Constable R, McCarthy G, Allison T, Anderson A, Gore J. Functional brain imaging at 1.5 T using conventional gradient echo MR imaging techniques. Magnetic Resonance Imaging 1993, 11: 451-459. PMID: 8316058, DOI: 10.1016/0730-725x(93)90463-n.Peer-Reviewed Original ResearchConceptsMotor cortexUse of MRMR imaging techniquesMotor areaEffects of activationNormal volunteersFrontal lobeVisual cortexMR imaging methodsBrain functionFunctional brainCortexExcellent depictionStimulus parametersVisual stimuliBrainGradient-echo imaging sequenceSignal changesImaging sequenceImaging techniquesSimilar responsesMsecActivationPhysiological responsesClinical scanner