2023
Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance
Ju S, Horien C, Shen X, Abuwarda H, Trainer A, Constable R, Fredericks C. Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance. Frontiers In Dementia 2023, 2: 1126016. PMID: 39082002, PMCID: PMC11285565, DOI: 10.3389/frdem.2023.1126016.Peer-Reviewed Original ResearchDefault mode networkConnectome-based predictive modelingMemory performanceMemory taskMemory scoresShort-term memory performanceBrain-based predictorsShort-term memoryPosterior default mode networkAmnestic Alzheimer's diseaseRecollective memoryDMN activityMode networkVisual networkPast researchSex-specific modelsVisual circuitryAlzheimer's diseaseSex differencesMemoryDifferent circuitryTaskElevated riskMachine learning approachesNetwork activity
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkRobust prediction of memory and neuroticism in men and women using connectome‐based predictive modeling
Ju S, Horien C, Constable T, Fredericks C. Robust prediction of memory and neuroticism in men and women using connectome‐based predictive modeling. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063015.Peer-Reviewed Original ResearchConnectome-based predictive modelingAlzheimer's diseaseRAVLT measuresFunctional MRI scansBackground Alzheimer's diseaseHealthy womenNeurobehavioral scoresHealthy subjectsHigh riskMemory performanceMRI scansBrain circuitryBrain connectivityWomenMenSexBrain connectomeDiseasePearson correlationScoresPredictorsConnectivity matrixBrain-based predictorsBehavioral measuresSubjects
2021
Sex differences in connectivity in the default mode network in healthy aging adults
Ficek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.Peer-Reviewed Original ResearchIntrinsic connectivity distributionDefault mode networkAlzheimer's diseaseHealthy aging adultsElevated riskAging AdultsLarge cross-sectional studyPosterior default mode networkSex differencesMode networkCross-sectional cohortCross-sectional studyPreclinical Alzheimer's diseaseSymptomatic Alzheimer's diseaseResting-state scansSex-based differencesAnterior nodeAD showDMN connectivityHealthy adultsFunctional MRI dataNormal individualsResults FemalesZ-scoreFunctional connectivity