Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin
Lizak M, Yarovinsky TO. Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Cell Host & Microbe 2012, 11: 70-80. PMID: 22264514, PMCID: PMC3266557, DOI: 10.1016/j.chom.2011.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBacterial ToxinsBody TemperatureBody WeightCell LineCell SurvivalDisease Models, AnimalEpithelial CellsHemolysin ProteinsHumansInterferon-alphaLipoylationMiceMice, KnockoutPhospholipid Transfer ProteinsProtein Processing, Post-TranslationalStaphylococcal InfectionsStaphylococcus aureusSurvival AnalysisConceptsLung epithelial cellsI interferonΑ-toxinStaphylococcal α-toxinCytolytic activityPhospholipid scramblase 1Epithelial cellsInnate protective mechanismsCause of pneumoniaHuman lung epithelial cellsType I interferonAureus clinical isolatesPore-forming toxinsMajor virulence factorScramblase 1Intracellular ATP depletionPositive pathogen Staphylococcus aureusMice displayClinical isolatesAureus strainsProtective mechanismCellular depletionBacterial pore-forming toxinsVirulence factorsUnderlying mechanism