Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 9333-9338. PMID: 16754872, PMCID: PMC1482610, DOI: 10.1073/pnas.0600905103.Peer-Reviewed Original ResearchConceptsRole of DATFunctional dopamine transporterDopamine transporterCocaine rewardSerotonin transporterNorepinephrine transporterExtracellular DAKnockout miceCocaine-insensitive dopamine transporterRole of NETNET knockout miceDAT knockout miceSelf-administer cocaineKnockin mouse lineMouse modelNucleus accumbensDopamine hypothesisPlace preferenceDA hypothesisLocomotor activityReward pathwayBehavioral effectsMiceMouse lines