2004
Translational autoregulation of thymidylate synthase and dihydrofolate reductase.
Tai N, Schmitz JC, Liu J, Lin X, Bailly M, Chen TM, Chu E. Translational autoregulation of thymidylate synthase and dihydrofolate reductase. Frontiers In Bioscience-Landmark 2004, 9: 2521-6. PMID: 15353304, DOI: 10.2741/1413.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorDNA RepairDrug ResistanceGene Expression Regulation, EnzymologicHumansIn Vitro TechniquesProtein BindingProtein BiosynthesisRNATetrahydrofolate DehydrogenaseThymidylate SynthaseConceptsSpecific RNA-protein interactionsRNA-protein interactionsVivo experimental model systemsAutoregulatory feedback mechanismFolate-dependent enzymesTranslational repressionTranslational autoregulationCognate mRNADNA repairMolecular basisExperimental model systemTS proteinDHFR mRNAMolecular elementsCellular drug resistanceNucleotide precursorsFunctional consequencesDihydrofolate reductaseDHFR expressionAutoregulatory controlDNA synthesisEssential roleEnzyme catalysisThymidylate synthaseModel system
2001
Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance
Schmitz J, Liu J, Lin X, Chen T, Yan W, Tai N, Gollerkeri A, Chu E. Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance. Cancer And Metastasis Reviews 2001, 20: 33-41. PMID: 11831645, DOI: 10.1023/a:1013100306315.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsDrug Resistance, NeoplasmGene Expression Regulation, EnzymologicHumansNeoplasmsProtein BiosynthesisTetrahydrofolate DehydrogenaseThymidylate SynthaseTumor Suppressor Protein p53