Translational autoregulation of thymidylate synthase and dihydrofolate reductase.
Tai N, Schmitz JC, Liu J, Lin X, Bailly M, Chen TM, Chu E. Translational autoregulation of thymidylate synthase and dihydrofolate reductase. Frontiers In Bioscience-Landmark 2004, 9: 2521-6. PMID: 15353304, DOI: 10.2741/1413.Peer-Reviewed Original ResearchConceptsSpecific RNA-protein interactionsRNA-protein interactionsVivo experimental model systemsAutoregulatory feedback mechanismFolate-dependent enzymesTranslational repressionTranslational autoregulationCognate mRNADNA repairMolecular basisExperimental model systemTS proteinDHFR mRNAMolecular elementsCellular drug resistanceNucleotide precursorsFunctional consequencesDihydrofolate reductaseDHFR expressionAutoregulatory controlDNA synthesisEssential roleEnzyme catalysisThymidylate synthaseModel system