2013
Inducible mouse models illuminate parameters influencing epigenetic inheritance
Wan M, Gu H, Wang J, Huang H, Zhao J, Kaundal RK, Yu M, Kushwaha R, Chaiyachati BH, Deerhake E, Chi T. Inducible mouse models illuminate parameters influencing epigenetic inheritance. Development 2013, 140: 843-852. PMID: 23325759, PMCID: PMC3557779, DOI: 10.1242/dev.088229.Peer-Reviewed Original ResearchConceptsTransgenerational inheritanceEpigenetic perturbationsModification patternsChromatin modification patternsRepressive chromatin modificationsAberrant epigenetic modificationsTarget gene sequenceMitotic inheritanceChromatin modificationsEpigenetic inheritanceEpigenetic stateMetastable epiallelesEpigenetic modificationsTranscription factorsGene sequencesDNA sequencesEpigenetic programmingTarget genesCOL1A1 locusFetal epigenomeExtraordinary malleabilityPleiotropic effectsInducible mouse modelEpigenomeTransient manipulation
2002
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 2002, 418: 195-199. PMID: 12110891, DOI: 10.1038/nature00876.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCD8 AntigensChromatinCross-Linking ReagentsDNA HelicasesDNA-Binding ProteinsFlow CytometryGene Expression RegulationGene SilencingMacromolecular SubstancesMiceMice, TransgenicMutationNuclear ProteinsProtein BindingProtein Structure, TertiaryProtein SubunitsThymus GlandTranscription FactorsConceptsBAF complexCD4 silencerYeast SWI/SNF complexSWI/SNF-like BAF complexHigh mobility group domainSWI/SNF complexLineage-specific genesDNA-binding subunitLineage bifurcationChromatin remodellingHMG domainChromatin lociSNF complexDNA bendingReciprocal regulationGroup domainCD4/CD8 expressionCell killingThymic developmentSilencerMutationsComplexesExpressionBAF57BRG