2013
Inducible mouse models illuminate parameters influencing epigenetic inheritance
Wan M, Gu H, Wang J, Huang H, Zhao J, Kaundal RK, Yu M, Kushwaha R, Chaiyachati BH, Deerhake E, Chi T. Inducible mouse models illuminate parameters influencing epigenetic inheritance. Development 2013, 140: 843-852. PMID: 23325759, PMCID: PMC3557779, DOI: 10.1242/dev.088229.Peer-Reviewed Original ResearchConceptsTransgenerational inheritanceEpigenetic perturbationsModification patternsChromatin modification patternsRepressive chromatin modificationsAberrant epigenetic modificationsTarget gene sequenceMitotic inheritanceChromatin modificationsEpigenetic inheritanceEpigenetic stateMetastable epiallelesEpigenetic modificationsTranscription factorsGene sequencesDNA sequencesEpigenetic programmingTarget genesCOL1A1 locusFetal epigenomeExtraordinary malleabilityPleiotropic effectsInducible mouse modelEpigenomeTransient manipulationBRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling
Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The EMBO Journal 2013, 32: 395-408. PMID: 23321680, PMCID: PMC3567501, DOI: 10.1038/emboj.2012.350.Peer-Reviewed Original ResearchConceptsTreg activationRegulatory T cellsSeverity of inflammationChemokine receptor genesT-cell lineageΑβ T cell lineagesCD4 cellsSuppress autoimmunityProinflammatory roleImmune toleranceFatal inflammationT cellsInflammatory cuesTregsInflammationBrg1 deletionReceptor geneChromatin-remodelling factor BRG1Activation levelsActivationCell lineagesTarget genesATPase activityPoint mutationsCells
2008
Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development
Yu M, Wan M, Zhang J, Wu J, Khatri R, Chi T. Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3873-3878. PMID: 18322012, PMCID: PMC2268827, DOI: 10.1073/pnas.0800810105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensChromatin ImmunoprecipitationEnhancer Elements, GeneticGene DeletionGene Expression RegulationHistonesLymphocyte SubsetsMiceMice, Inbred C57BLModels, BiologicalNucleoproteinsPromoter Regions, GeneticProtein BindingSilencer Elements, TranscriptionalT-LymphocytesTranscription FactorsConceptsT cell developmentCell developmentNucleoprotein structuresCD4 locusHeterochromatin-like structureOpen chromatin configurationStage-specific mannerSame regulatory elementsDP cellsRepression patternsTranscription activatorCD4 silencerP300 recruitmentChromatin configurationRegulatory elementsDN cellsMolecular basisMolecular mechanismsCD4 enhancerCD4 transcriptionMature T cellsCD4 regulationCD4 geneCD4 promoterSilencer