PPARγ phase separates with RXRα at PPREs to regulate target gene expression
Li Z, Luo L, Yu W, Li P, Ou D, Liu J, Ma H, Sun Q, Liang A, Huang C, Chi T, Huang X, Zhang Y. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discovery 2022, 8: 37. PMID: 35473936, PMCID: PMC9043196, DOI: 10.1038/s41421-022-00388-0.Peer-Reviewed Original ResearchPPAR response elementNuclear condensatesTranscriptional activationPPRE siteZinc finger motifsDNA binding domainsKey transcription activatorSpecific transcriptional activationTarget gene expressionPPARγ/RXRαRetinoid X receptor αPPARγ target genesFinger motifPhase-separated dropletsTranscription activatorTranscriptional responseObligate heterodimersTarget genesX receptor αBinding domainsGene expressionResponse elementPeroxisome proliferator-activated receptorNovel mechanismProliferator-activated receptor