2013
BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling
Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The EMBO Journal 2013, 32: 395-408. PMID: 23321680, PMCID: PMC3567501, DOI: 10.1038/emboj.2012.350.Peer-Reviewed Original ResearchConceptsTreg activationRegulatory T cellsSeverity of inflammationChemokine receptor genesT-cell lineageΑβ T cell lineagesCD4 cellsSuppress autoimmunityProinflammatory roleImmune toleranceFatal inflammationT cellsInflammatory cuesTregsInflammationBrg1 deletionReceptor geneChromatin-remodelling factor BRG1Activation levelsActivationCell lineagesTarget genesATPase activityPoint mutationsCells
2008
A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development
Jani A, Wan M, Zhang J, Cui K, Wu J, Preston-Hurlburt P, Khatri R, Zhao K, Chi T. A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development. Journal Of Experimental Medicine 2008, 205: 2813-2825. PMID: 18955569, PMCID: PMC2585832, DOI: 10.1084/jem.20080938.Peer-Reviewed Original ResearchConceptsPoint mutantsUnexpected roleImportant gene functionsThymocyte developmentNovel genetic strategyPoint mutationsEarly thymocyte developmentMammalian geneticsChromatin templatesSWI-SNFBAF complexGene functionATPase subunitsDeletion mutantsFactor complexCD4 locusTarget genesGenetic strategiesCD4 activationMutantsNovel activityPhysical interactionDeletionBRGMutations