2022
iMAPping the Perturb-Atlas
Sun Y, Lin W, Kaundal R, Chi T. iMAPping the Perturb-Atlas. Life Medicine 2022, 2: lnac057. DOI: 10.1093/lifemedi/lnac057.Peer-Reviewed Original Research
2017
Chapter 15 Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
Mao S, Li Y, Liu B, Chi T. Chapter 15 Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies. 2017, 231-243. DOI: 10.1016/b978-0-12-805388-1.00015-8.Peer-Reviewed Original ResearchEpigenetic inheritanceChromatin modificationsHeritable chromatin modificationsHeritable epigenetic statesSimple reporter geneEpigenetic stateExperimental strategiesEpigenetic mechanismsMolecular basisReporter geneMouse modelInheritanceInheritance modelEnvironmental factorsCompelling evidenceMechanistic studiesEmbryogenesisExtensive contributionsGenesTraitsMechanismMechanistic problemsModificationInducerOffspring
2009
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling
Lai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundström T, Imbalzano AN, Chi T. Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1169-1174. PMID: 19164553, PMCID: PMC2633529, DOI: 10.1073/pnas.0811274106.Peer-Reviewed Original ResearchConceptsCalcium/CaMChromatin remodelingBAF complexSWI/SNF-like BAF chromatinTarget genesDominant negative mutantCalcium/calmodulinCalmodulin-dependent regulationHMG domainBAF chromatinCaM-binding peptideNegative mutantGene expressionCaM antagonistsGenesToll-like receptor 4ChromatinRegulationRemodelingRecruitmentComplexesBAF57RNAiMutantsInduction